Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Technology for Complex Trans-Media Pollution, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China.
Arch Toxicol. 2024 Jan;98(1):233-250. doi: 10.1007/s00204-023-03624-y. Epub 2023 Oct 21.
With the widespread use of organophosphate esters (OPEs), the accumulation and toxicity effect of OPEs in biota are attracting more and more concern. In order to clarify the mechanism of toxicity of OPEs to organisms, this study reviewed the OPEs toxicity and systematically identified the mechanism of OPEs toxicity under the framework of adverse outcome pathway (AOP). OPEs were divided into three groups (alkyl-OPEs, aryl-OPEs, and halogenated-OPEs) and biota was divided into aquatic organism and mammals. The results showed that tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP) mainly caused neurotoxicity, reproductive, and hepatotoxicity in different mechanisms. According to the constructed AOP network, the toxicity mechanism of OPEs on aquatic organisms and mammals is different, which is mainly attributed to the different biological metabolic systems of aquatic organisms and mammals. Interestingly, our results indicate that the toxicity effect of the three kinds of OPEs on aquatic organisms is different, while there was no obvious difference in the mechanism of toxicity of OPEs on mammals. This study provides a theoretical basis for OPEs risk assessment in the future.
随着有机磷酸酯（OPEs）的广泛使用，OPEs 在生物体内的积累和毒性效应越来越受到关注。为了阐明 OPEs 对生物体的毒性机制，本研究综述了 OPEs 的毒性，并在不良结局途径（AOP）框架下系统地确定了 OPEs 毒性的机制。OPEs 分为三组（烷基-OPEs、芳基-OPEs 和卤代-OPEs），生物群分为水生生物和哺乳动物。结果表明，三（1,3-二氯-2-丙基）磷酸酯（TDCIPP）和磷酸三苯酯（TPHP）主要通过不同机制引起神经毒性、生殖毒性和肝毒性。根据构建的 AOP 网络，OPEs 对水生生物和哺乳动物的毒性机制不同，这主要归因于水生生物和哺乳动物不同的生物代谢系统。有趣的是，我们的结果表明，三种 OPEs 对水生生物的毒性效应不同，而 OPEs 对哺乳动物的毒性机制则没有明显差异。本研究为未来 OPEs 风险评估提供了理论依据。
