Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of China.
Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of China.
Environ Int. 2023 Nov;181:108253. doi: 10.1016/j.envint.2023.108253. Epub 2023 Oct 13.
Lead is a common environmental heavy metal contaminant. Humans are highly susceptible to lead accumulation in the body, which causes nervous system damage and leads to a variety of nervous system diseases, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. Recent research has focused on the mechanisms of lead-induced neurotoxicity at multiple levels, including DNA methylation, histone modifications, and non-coding RNAs, which are involved in various lead-induced nervous system diseases. We reviewed the latest articles and summarised the emerging roles of DNA methylation, histone modification, and non-coding RNAs in lead-induced neurotoxicity. Our summary provides a theoretical basis and directions for future research on the prevention, diagnosis, and treatment of lead-induced neurological diseases.
铅是一种常见的环境重金属污染物。人类极易受到体内铅积累的影响，这会导致神经系统损伤，并引发多种神经系统疾病，如老年痴呆症、帕金森病和自闭症谱系障碍。最近的研究集中在铅诱导的神经毒性的多种机制上，包括 DNA 甲基化、组蛋白修饰和非编码 RNA，这些机制参与了各种由铅引起的神经系统疾病。我们综述了最新的文章，总结了 DNA 甲基化、组蛋白修饰和非编码 RNA 在铅诱导的神经毒性中的新兴作用。我们的总结为预防、诊断和治疗铅诱导的神经疾病提供了理论基础和研究方向。
