Wang Ping, Wu Zhiling, Li Ju, Li Yue, Wang Xuefeng, Ma Mengya, Wei Wenkai, Wang Yijun, Liu Yi, Sun Yi, Tao Ling, Yang Yanyan, Zhou Ziyuan, Ren Jingchao, Cao Jia, Zhang Guanghui
Department of Labor Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Toxics. 2025 May 21;13(5):415. doi: 10.3390/toxics13050415.
Lead (Pb) is recognized as an environmental pollutant with male reproductive toxicity, but its effects on sex hormones remain unclear. This study investigated the relationship between male blood lead levels (BLLs) and the sex hormones of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL), as well as testosterone (T), estrogen (E2), and progesterone (PROG). Observational and experimental data from 1573 Pb-exposed workers (712 had also been surveyed in the previous year) and 35 Pb-poisoned patients (before and after Pb chelation therapy) were analyzed. Results from a cross-sectional study showed a nonlinear relationship between BLLs and LH/FSH, and a linear relationship between BLLs and serum T. After Pb chelation therapy, the BLLs in patients decreased from 61.7 to 36.3 (μg/dL), serum T and FSH decreased significantly ( < 0.001), and serum LH also decreased but without a significant change, while PRL and PROG increased significantly ( < 0.01). The data indicate that Pb may disturb male sex hormones by including LH, T, and FSH, and this needs further research.
铅（Pb）被公认为是一种具有男性生殖毒性的环境污染物，但其对性激素的影响仍不明确。本研究调查了男性血铅水平（BLLs）与促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）以及睾酮（T）、雌激素（E2）和孕酮（PROG）等性激素之间的关系。分析了1573名铅暴露工人（其中712人在前一年也接受了调查）以及35名铅中毒患者（铅螯合治疗前后）的观察性和实验性数据。横断面研究结果显示，BLLs与LH/FSH之间存在非线性关系，BLLs与血清T之间存在线性关系。铅螯合治疗后，患者的BLLs从61.7降至36.3（μg/dL），血清T和FSH显著降低（<0.001），血清LH也有所下降但无显著变化，而PRL和PROG显著升高（<0.01）。数据表明，铅可能通过影响LH、T和FSH来干扰男性性激素，这有待进一步研究。
