Departmenmt of Agricultural Biotechnology, Faculty of Postgraduate, Jendral Soedirman University, Dr. Suparno Street, Karangwangkal, Puwokerto, Central Java 53122, Indonesia.
Faculty of Animal Science, Jendral Soedirman University, Dr. Suparno Street, Karangwangkal, Puwokerto, Central Java 53122, Indonesia.
Res Vet Sci. 2023 Dec;165:105057. doi: 10.1016/j.rvsc.2023.105057. Epub 2023 Oct 16.
This review article aimed to provide readers with a comprehensive understanding of the function of heat shock proteins (HSPs) in chicken physiology, stress response, and overall poultry health. With the increasing challenges faced by the livestock industry, particularly the poultry sector, due to climate change-induced high ambient temperatures, heat stress (HS) has become a critical concern. HS disrupts the thermal balance in poultry, leading to detrimental effects on growth, immune function, and overall health. HSPs play a pivotal role in mitigating the impacts of HS in chickens. These molecular chaperones are involved in protein folding, unfolding, and assembly, and they are classified into several families based on their size, including small molecule HSPs, HSP40, HSP60, HSP70, HSP90, and HSP110. By maintaining cellular homeostasis and promoting stress tolerance, HSPs act as vital guardians in helping chickens cope with HS and its associated consequences. The review synthesized relevant literature to shed light on the importance of HSPs in stress adaptation, cellular homeostasis, and the maintenance of normal cell metabolism in chickens. The adverse effects of HS on chickens include oxidative stress and compromised immune systems, making them more susceptible to infections. So also, HS negatively affects production performance and meat quality in poultry. Understanding the functions of HSPs in chickens offers valuable insights into stress adaptation and health, and could potentially lead to the identification of HSP biomarkers, genetic selection for heat tolerance, investigations into the interplay between HSPs and immune function, and the development of nutritional interventions to enhance HSP activity. By exploring these potential research directions, the review aimed to contribute to the development of novel approaches to mitigate the negative effects of HS on poultry, ultimately improving productivity and animal welfare in a changing climate.
这篇综述文章旨在为读者提供对热休克蛋白（HSPs）在鸡生理、应激反应和整体家禽健康中的功能的全面理解。随着畜牧业，特别是家禽业面临的挑战不断增加，由于气候变化引起的环境高温，热应激（HS）已成为一个关键问题。HS 破坏了家禽的热平衡，对生长、免疫功能和整体健康产生不利影响。HSPs 在减轻鸡的 HS 影响方面起着关键作用。这些分子伴侣参与蛋白质折叠、展开和组装，根据它们的大小，它们被分为几个家族，包括小分子 HSPs、HSP40、HSP60、HSP70、HSP90 和 HSP110。通过维持细胞内稳态和促进应激耐受，HSPs 作为重要的守护者，帮助鸡应对 HS 及其相关后果。该综述综合了相关文献，阐明了 HSPs 在应激适应、细胞内稳态和维持鸡正常细胞代谢中的重要性。HS 对鸡的不利影响包括氧化应激和免疫系统受损，使它们更容易感染。此外，HS 还会对家禽的生产性能和肉品质产生负面影响。了解 HSPs 在鸡中的功能为应激适应和健康提供了有价值的见解，并可能导致 HSP 生物标志物的识别、耐热性的遗传选择、HSPs 与免疫功能之间相互作用的研究以及增强 HSP 活性的营养干预措施的开发。通过探索这些潜在的研究方向，该综述旨在为减轻 HS 对家禽的负面影响的新方法的发展做出贡献，最终在不断变化的气候条件下提高生产力和动物福利。
