Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Biomed Pharmacother. 2023 Dec;168:115748. doi: 10.1016/j.biopha.2023.115748. Epub 2023 Oct 20.
Nuclear factor erythroid-2-related factor 2 (Nrf2) plays an important role in maintaining cellular homeostasis, as it suppresses cell damage caused by external stimuli by regulating the transcription of intracellular defense-related genes. Accumulating evidence has highlighted the crucial role of reduction-oxidation (REDOX) imbalance in the development of bone-related diseases. Nrf2, a transcription factor linked to nuclear factor-erythrocyte 2, plays a pivotal role in the regulation of oxidative stress and induction of antioxidant defenses. Therefore, further investigation of the mechanism and function of Nrf2 in bone-related diseases is essential. Considerable evidence suggests that increased nuclear transcription of Nrf2 in response to external stimuli promotes the expression of intracellular antioxidant-related genes, which in turn leads to the inhibition of bone remodeling imbalance, improved fracture recovery, reduced occurrence of osteoarthritis, and greater tumor resistance. Certain natural extracts can selectively target Nrf2, potentially offering therapeutic benefits for osteogenic arthropathy. In this article, the biological characteristics of Nrf2 are reviewed, the intricate interplay between Nrf2-regulated REDOX imbalance and bone-related diseases is explored, and the potential preventive and protective effects of natural products targeting Nrf2 in these diseases are elucidated. A comprehensive understanding of the role of Nrf2 in the development of bone-related diseases provides valuable insights into clinical interventions and can facilitate the discovery of novel Nrf2-targeting drugs.
核因子红细胞 2 相关因子 2（Nrf2）在维持细胞内稳态方面发挥着重要作用，它通过调节细胞内防御相关基因的转录来抑制外部刺激引起的细胞损伤。越来越多的证据强调了氧化还原（REDOX）失衡在骨相关疾病发展中的关键作用。Nrf2 是一种与核因子红细胞 2 相关的转录因子，在氧化应激的调节和抗氧化防御的诱导中起着关键作用。因此，进一步研究 Nrf2 在骨相关疾病中的机制和功能至关重要。有大量证据表明，Nrf2 在外源刺激下的核转录增加可促进细胞内抗氧化相关基因的表达，从而抑制骨重塑失衡，改善骨折恢复，减少骨关节炎的发生，提高肿瘤的耐药性。某些天然提取物可以选择性地针对 Nrf2，可能为成骨性关节炎提供治疗益处。本文综述了 Nrf2 的生物学特性，探讨了 Nrf2 调节的 REDOX 失衡与骨相关疾病之间的复杂相互作用，并阐明了针对这些疾病的天然产物靶向 Nrf2 的潜在预防和保护作用。全面了解 Nrf2 在骨相关疾病发展中的作用为临床干预提供了有价值的见解，并有助于发现新型 Nrf2 靶向药物。
