Department of Pharmacy, the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213100, China.
Department of Pharmacy, the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213100, China.
Colloids Surf B Biointerfaces. 2023 Dec;232:113598. doi: 10.1016/j.colsurfb.2023.113598. Epub 2023 Oct 17.
Kidney disease is one of the most life-threatening health problems, affecting millions of people in the world. Commonly used steroids and immunosuppressants often fall exceptionally short of outcomes with inescapable systemic toxicity. With the booming research in nanobiotechnology, stimuli-responsive nanoplatform has come an appealing therapeutic strategy for kidney disease. Endogenous stimuli-responsive materials have shown profuse promise owing to their enhanced spatiotemporal control and precise to the location of the lesion. This review focuses on recent advances stimuli-responsive drug delivery nano-architectonics for kidney disease. First, a brief introduction of pathogenesis of kidney disease and pathological microenvironment were provided. Then, various endogenous stimulus involved in drug delivery nanoplatforms including pH, ROS, enzymes, and glucose were categorized based on the pathological mechanisms of kidney disease. Next, we separately summarized literature examples of endogenous stimuli-responsive nanomaterials, and outlined the design strategies and response mechanisms. Finally, the paper was concluded by discussing remaining challenges and future perspectives of endogenous stimuli-responsive drug delivery nanoplatform for expediting the speed of development and clinical applications.
肾脏疾病是威胁生命的最严重健康问题之一，影响着全球数百万人。常用的类固醇和免疫抑制剂往往在不可避免的全身毒性方面效果不佳。随着纳米生物技术的蓬勃发展，刺激响应型纳米平台已成为治疗肾脏疾病的一种有吸引力的治疗策略。内源性刺激响应材料由于具有增强的时空控制和对病变部位的精确性，显示出了丰富的前景。本综述重点介绍了用于肾脏疾病的刺激响应药物传递纳米结构的最新进展。首先，简要介绍了肾脏疾病的发病机制和病理微环境。然后，根据肾脏疾病的病理机制，将涉及药物传递纳米平台的各种内源性刺激（包括 pH、ROS、酶和葡萄糖）进行了分类。接下来，我们分别总结了内源性刺激响应纳米材料的文献实例，并概述了设计策略和响应机制。最后，通过讨论内源性刺激响应药物传递纳米平台的剩余挑战和未来展望，为加快发展和临床应用的速度进行了总结。
