Bang Ngo Anh, Hai Yen Duong Thi, Thuy Hang Dan Thi, Yen Pham Hai, Hoang Nguyen Huy, Trang Do Thi, Dung Duong Thi, Cuc Nguyen Thi, Cuong Nguyen The, Nhiem Nguyen Xuan, Tai Bui Huu, Van Kiem Phan
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam
Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.
RSC Adv. 2024 Jul 1;14(29):20536-20542. doi: 10.1039/d4ra02968b. eCollection 2024 Jun 27.
Phytochemical studies on plants have attracted considerable attention over the past few decades due to the structural diversities and significant biological activities of terpenoids produced by these plants. In the present study, five new acyclic diterpene lactone derivatives, aphanamixionolides A-E (1-5), and three known tirucallane-type triterpenes, namely, piscidinol A (6), hispidone (7), and bourjotinolone A (8), were isolated from the leaves of . Their structures were elucidated by comprehensive analyses of HR-ESI-MS and NMR spectroscopic data and by comparison with those reported in the literature. Absolute configurations of the new compounds were determined by experimental and TD-DFT calculated ECD spectra. Compounds 1-8 inhibited NO production with IC values of 10.2-37.7 μM, which are comparable to positive control l-NMMA (IC: 31.5 μM).
在过去几十年里，对植物的植物化学研究引起了相当大的关注，因为这些植物产生的萜类化合物具有结构多样性和显著的生物活性。在本研究中，从[植物名称]的叶子中分离出了五种新的无环二萜内酯衍生物，即阿法那米西内酯A-E（1-5），以及三种已知的四环三萜，即哌西地诺醇A（6）、糙叶花椒酮（7）和布尔乔蒂诺酮A（8）。通过对高分辨电喷雾电离质谱（HR-ESI-MS）和核磁共振光谱数据的综合分析，并与文献报道的数据进行比较，阐明了它们的结构。通过实验和含时密度泛函理论（TD-DFT）计算的电子圆二色光谱（ECD）确定了新化合物的绝对构型。化合物1-8抑制一氧化氮（NO）生成，其半数抑制浓度（IC）值为10.2-37.7 μM，与阳性对照L-硝基精氨酸甲酯（L-NMMA，IC：31.5 μM）相当。
