Luo De, Mei Bingjie, Wang Piao, Li Xujia, Chen Xinpei, Wei Gang, Kuang Fei, Li Bo, Su Song
Department of General Surgery (Hepatopancreatobiliary Surgery), Affiliated Hospital of Southwest Medical University, Sichuan, China; Academician (Expert) Workstation of Sichuan Province, Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, Affiliated Hospital of Southwest Medical University, Sichuan, China.
School of Medicine, University of Electronic Science and Technology of China, Sichuan Cancer Hospital, Sichuan, China.
Clin Microbiol Infect. 2024 Mar;30(3):328-335. doi: 10.1016/j.cmi.2023.10.016. Epub 2023 Oct 20.
Long-term physical and mental persistent symptoms after COVID-19 represent a growing global public health concern. However, there remains a substantial knowledge gap regarding their prevalence and risk factors.
To estimate the prevalence and risk factors for persistent symptoms after COVID-19.
We used a random-effects model to pool persistent symptom prevalence and risk ratios comparing COVID-19 patients with non-COVID-19 individuals.
Electronic databases were searched for studies published from December 2019 to January 2023.
Eligible studies that reported the prevalence and risk factors for persistent symptoms after COVID-19 were included.
Patients who recovered from COVID-19.
The Joanna Briggs Institute critical appraisal tool was used to assess the risk of bias in prevalence studies, whereas the risk of bias in cohort studies was evaluated with the Newcastle-Ottawa Scale.
After screening 4359 studies, a total of 211 eligible studies were included, covering a population of 13 368 074 individuals. Fatigue, dyspnoea, post-traumatic stress disorder, anxiety, and depression were the most frequently reported persistent symptoms after COVID-19. Subgroup analyses revealed that individuals with more severe illness in the acute phase or from Europe exhibited a higher prevalence of certain symptoms, whereas children demonstrated a lower prevalence. Furthermore, COVID-19 patients had a significantly higher prevalence of most persistent symptoms compared with non-COVID-19 individuals. Factors frequently associated with a higher prevalence of persistent symptoms included female gender, advanced age, severe illness during the acute phase of COVID-19, multiple comorbidities, an extended duration of hospital stay, and a high body mass index.
This meta-analysis provides a thorough review of the prevalence and risk factors for persistent symptoms following COVID-19. The findings underscore the importance of long-term monitoring and support for individuals recovering from COVID-19.
新型冠状病毒肺炎（COVID-19）后长期的身心持续症状成为日益严重的全球公共卫生问题。然而，关于其患病率和风险因素仍存在相当大的知识空白。
估计COVID-19后持续症状的患病率和风险因素。
我们使用随机效应模型汇总持续症状患病率和风险比，比较COVID-19患者与非COVID-19个体。
检索电子数据库中2019年12月至2023年1月发表的研究。
纳入报告COVID-19后持续症状患病率和风险因素的合格研究。
从COVID-19中康复的患者。
使用乔安娜·布里格斯研究所的批判性评价工具评估患病率研究中的偏倚风险，而队列研究中的偏倚风险则用纽卡斯尔-渥太华量表进行评估。
在筛查4359项研究后，共纳入211项合格研究，涵盖13368074人。疲劳、呼吸困难、创伤后应激障碍、焦虑和抑郁是COVID-19后最常报告的持续症状。亚组分析显示，急性期病情较重的个体或来自欧洲的个体某些症状的患病率较高，而儿童的患病率较低。此外，与非COVID-19个体相比，COVID-19患者大多数持续症状的患病率显著更高。与持续症状患病率较高经常相关的因素包括女性、高龄、COVID-19急性期的重病、多种合并症、住院时间延长和高体重指数。
这项荟萃分析全面回顾了COVID-19后持续症状患病率和风险因素。研究结果强调了对从COVID-19中康复的个体进行长期监测和支持的重要性。
