Ren Chenyang, Hou Ping, Li Jian, Huang Yan, Pan Liwei, Peng Liuting, Gan Chunqiu, Guan Xinlan, Li Jun
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Peoples' Hospital of Pubei, Pubei, China.
Nat Prod Res. 2025 Feb;39(3):475-482. doi: 10.1080/14786419.2023.2272284. Epub 2023 Oct 22.
A new megastigmane glycoside, barbatcoside A (), and two new phenol glycosides, barbatcosides B () and C (), together with eight known compounds (-) were isolated from the bark of Müll. Arg. Their structures were elucidated using extensive 1D and 2D NMR as well as HRESIMS spectroscopic data. The stereochemistry of compounds and were established based on the experimental CD curves. The anti-inflammatory activities of compounds - from were evaluated using LPS-stimulated RAW 264.7 cell models. Compounds and substantially inhibited the release of NO with IC values of 34.78 M and 20.73 M, respectively.
从毛叶巴豆（Müll. Arg.）的树皮中分离出一种新的巨大戟烷糖苷， barbatusoside A（ ），以及两种新的酚糖苷，barbatusoside B（ ）和C（ ），同时还分离出8种已知化合物（ - ）。通过广泛的一维和二维核磁共振以及高分辨电喷雾电离质谱光谱数据阐明了它们的结构。基于实验性圆二色曲线确定了化合物 和 的立体化学。使用脂多糖刺激的RAW 264.7细胞模型评估了来自 的化合物 - 的抗炎活性。化合物 和 分别以34.78 μM和20.73 μM的半数抑制浓度显著抑制一氧化氮的释放。
