Chang Yanling, Liang Xiaoqin, Huang Yan, Ren Chenyang, Hou Ping, Pan Liwei, Li Jun
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, China.
College of Chemical and Biological Engineering, Hechi University, Yizhou, China.
Nat Prod Res. 2025 Apr;39(7):1968-1974. doi: 10.1080/14786419.2023.2286601. Epub 2023 Nov 27.
Three undescribed megastigmane glycosides, mallbarbalosides A-C together with 3 known analogues were isolated from the stem of . Their structures were elucidated using extensive NMR spectroscopic methods (1D and 2D-NMR spectroscopy) and HRESIMS spectroscopic data analyses. The absolute configurations of the undescribed compounds were determined by the experimental circular dichroism spectroscopy. All the compounds were tested for their inhibitory effects on the production of NO in LPS-treated RAW 264.7 cells, and they showed no inhibitory effect to NO release.
从[植物名称]茎中分离得到3个未描述的大柱香波龙苷类化合物，即mallbarbalosides A - C以及3个已知类似物。通过广泛的核磁共振光谱方法（一维和二维核磁共振光谱）和高分辨电喷雾电离质谱光谱数据分析对其结构进行了阐明。通过实验性圆二色光谱确定了未描述化合物的绝对构型。测试了所有化合物对脂多糖处理的RAW 264.7细胞中一氧化氮产生的抑制作用，结果显示它们对一氧化氮释放没有抑制作用。
