Singer Cristina Elena, Biciuşcă Viorel, Abdul-Razzak Jaqueline, Popescu Iulian Alin Silviu, Geormăneanu Cristiana, Singer Maria Mădălina, Mărginean Cristina Maria, Popescu Mihaela
Department of Internal Medicine, Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2023 Jul-Sep;64(3):419-426. doi: 10.47162/RJME.64.3.13.
To study the causes of iron deficiency, laboratory findings and clinical manifestation of infants aged 6-12 months and children aged 1-3 years diagnosed with severe iron-deficiency anemia.
PATIENTS, MATERIALS AND METHODS: We conducted an observational, retrospective single tertiary center study between January 2015 and April 2022, which included 142 children. The control group (patients with no diagnosis of severe iron-deficiency anemia) included 71 patients and the study group (patients diagnosed with severe iron-deficiency anemia) included also 71 patients. Clinical data were retrospectively collected from hospital medical records. Statistical analysis was conducted using Statistical Package for the Social Sciences (SPSS) 25.0 software.
Seventy-one children had hemoglobin <7 g∕dL and low values of ferritin/serum iron (22 infants aged 6-12 months and 49 children aged 1-3 years). In both the study and control groups, the male gender was slightly more prevalent. Mother's age at birth and living standard is significantly lower in the study group. We note a higher frequency of premature births (14.08%) in children identified with anemia compared to control group (8.45%). We found a statistically significant distribution of cow's milk consumption among the two groups (p<0.001). Pearson's correlation test revealed a significant positive correlation, indicating that anemia is directly proportional to cow's milk consumption.
The most frequent cause of iron-deficiency anemia in infants and children 1-3 years old was the consumption of cow's milk following incorrect diversification and incomplete prophylaxis of iron-deficiency anemia.
研究6至12个月婴儿及1至3岁儿童被诊断为重度缺铁性贫血的缺铁原因、实验室检查结果及临床表现。
患者、材料与方法：我们在2015年1月至2022年4月期间进行了一项观察性、回顾性单中心三级研究，纳入了142名儿童。对照组（未诊断为重度缺铁性贫血的患者）包括71名患者，研究组（诊断为重度缺铁性贫血的患者）也包括71名患者。临床数据通过回顾医院病历收集。使用社会科学统计软件包（SPSS）25.0软件进行统计分析。
71名儿童血红蛋白<7 g∕dL且铁蛋白/血清铁值较低（22名6至12个月的婴儿和49名1至3岁的儿童）。在研究组和对照组中，男性的比例略高。研究组母亲的生育年龄和生活水平显著较低。我们注意到，与对照组（8.45%）相比，贫血儿童的早产频率更高（14.08%）。我们发现两组之间牛奶摄入量的分布具有统计学意义（p<0.001）。Pearson相关性检验显示出显著的正相关，表明贫血与牛奶摄入量成正比。
1至3岁婴幼儿缺铁性贫血最常见的原因是在缺铁性贫血的多样化不正确和预防不充分的情况下饮用牛奶。
