Nwachukwu Kingsley Chukwuemeka, Nwarunma Ebubechukwu, David Uchenna Chinaza, Chinyere Ugbogu Ositadinma
Department of Microbiology, Faculty of Biological Sciences, Abia State University, Uturu, Nigeria.
Department of Biological and Biomedical Science, School of Health and Life Sciences, Glasgow Caledonian University, Scotland, UK.
Curr Med Mycol. 2023 Mar;9(1):36-43. doi: 10.18502/CMM.2023.150673.
is an emerging pathogen predominantly isolated from immunocompromised patients, hospitalized for a long time. It inhabits the skin surfaces of patients causing ear, wound, and systemic infections; if not treated properly, it could lead to severe mortality. Apart from being a skin pathogen, colonizes the surfaces of medical devices. Medical devices are hospital tools and components often utilized for the diagnosis and treatment of diseases associated with human skin. The mechanism of survival and persistence of on medical devices has remained unclear and is a serious concern for clinicians. The persistence of on medical devices has deterred its effective elimination, hindered the treatment of infections, and increased its antifungal resistance. Evidence has shown that a few surface molecules on the cell wall of and the extracellular matrix of the biofilm are responsible for its persistence and exist as enablers. Due to the increased cases of ear, skin, and systemic infections as well as death resulting from the spread of in hospitals, there is a need to study these enablers. This review focused on the identification of the enablers and aimed to evaluate them in relation to their ability to induce persistence in . In order to reduce the spread of or completely eliminate and its enablers in hospitals, the efficacy of disinfection and sterilization methods were compared.
是一种新兴病原体，主要从长期住院的免疫功能低下患者中分离出来。它寄居于患者的皮肤表面，引发耳部、伤口及全身感染；若治疗不当，可能导致严重死亡。除了作为皮肤病原体外，它还能在医疗设备表面定殖。医疗设备是医院中常用于诊断和治疗与人类皮肤相关疾病的工具和部件。其在医疗设备上的存活和持续存在机制尚不清楚，这是临床医生严重关切的问题。它在医疗设备上的持续存在阻碍了其有效清除，妨碍了感染治疗，并增加了其抗真菌耐药性。有证据表明，其细胞壁上的一些表面分子以及生物膜的细胞外基质是其持续存在的原因，它们作为促成因素存在。由于医院中因传播导致的耳部、皮肤及全身感染病例增加以及死亡，有必要研究这些促成因素。本综述聚焦于促成因素的识别，并旨在根据它们诱导持续存在的能力对其进行评估。为了减少在医院中的传播或完全消除及其促成因素，对消毒和灭菌方法的效果进行了比较。
