Onset and duration of beta-adrenergic receptor blockade following single oral dose acebutolol hydrochloride (Sectral).
作者信息
Watson R D, Littler W A
出版信息
Br J Clin Pharmacol. 1979 Jun;7(6):557-61. doi: 10.1111/j.1365-2125.1979.tb04642.x.
Abstract
- The onset and duration of action of once daily acebutolol (400 mg) on resting and exercise heart rate and blood pressure were studied in normal subjects in a double-blind, cross-over trial against placebo. Subjects were studied 1.5, 3, 8 and 24 h after the first dose and 24 h after the fifth dose. 2. Resting and exercise heart rate and blood pressure were significantly reduced within 90 min of the first dose. 3. A significant reduction in these variables persisted throughout 24 h after the fifth daily dose. However, at 24 h the effects were considerably attenuated, the falls in resting and exercise systolic blood pressure being only 5%. 4. A linear relationship was noted between log serum drug level and percentage reduction of exercise heart rate.
摘要
相似文献
1
Onset and duration of beta-adrenergic receptor blockade following single oral dose acebutolol hydrochloride (Sectral).
Br J Clin Pharmacol. 1979 Jun;7(6):557-61. doi: 10.1111/j.1365-2125.1979.tb04642.x.
2
The beta-blocking effect of diacetolol in humans and its relationship to plasma levels.双醋洛尔在人体中的β受体阻滞作用及其与血浆水平的关系。
Int J Clin Pharmacol Ther Toxicol. 1982 Aug;20(8):358-61.
3
Comparative beta-blocking potencies of acebutolol and propranolol relative to plasma drug levels.醋丁洛尔和普萘洛尔相对于血浆药物水平的β受体阻滞效价比较。
Int J Clin Pharmacol Ther Toxicol. 1981 Nov;19(11):473-8.
4
5
6
Effect of acebutolol on dynamic ischemic ECG changes: a study using ambulatory twenty-four-hour ECG monitoring.醋丁洛尔对动态缺血性心电图改变的影响：一项使用24小时动态心电图监测的研究。
Isr J Med Sci. 1979 Mar;15(3):207-11.
7
Acebutolol in hypertension--double-blind trial against placebo.醋丁洛尔治疗高血压——与安慰剂对照的双盲试验
Br J Clin Pharmacol. 1978 Oct;6(4):351-6. doi: 10.1111/j.1365-2125.1978.tb00863.x.
8
Effect of acebutolol, a new beta-receptor antagonist on heart rate and rate-pressure product in normal subjects.新型β受体拮抗剂醋丁洛尔对正常受试者心率及心率-血压乘积的影响。
Int J Clin Pharmacol Biopharm. 1976 Dec;14(4):290-7.
9
Antiarrhythmic significance of dosing intervals in beta receptor blocking therapy of hypertension with acebutolol.醋丁洛尔治疗高血压时β受体阻滞剂给药间隔的抗心律失常意义
Am J Cardiol. 1981 Nov;48(5):911-6. doi: 10.1016/0002-9149(81)90358-1.
10
Acebultolol: basis for the prediction of effect on exercise tolerance.醋丁洛尔：预测对运动耐量影响的依据。
Clin Pharmacol Ther. 1976 Mar;19(3):333-8. doi: 10.1002/cpt1976193333.
引用本文的文献
1
Observations on the clinical pharmacology and plasma concentrations of diacetolol, the major human metabolite of acebutolol.醋丁洛尔的主要人体代谢物双醋洛尔的临床药理学及血药浓度观察
Br J Clin Pharmacol. 1981 Oct;12(4):561-5. doi: 10.1111/j.1365-2125.1981.tb01265.x.
2
Comparison of once and twice daily administration of acebutolol in hypertension.醋丁洛尔一日一次与一日两次给药治疗高血压的比较。
Br J Clin Pharmacol. 1980 Feb;9(2):209-12. doi: 10.1111/j.1365-2125.1980.tb05835.x.
3
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers.单次口服新型β-肾上腺素能受体阻滞剂倍他洛尔（SL 75212）对健康志愿者心血管系统的影响。
Br J Clin Pharmacol. 1980 Jun;9(6):569-75. doi: 10.1111/j.1365-2125.1980.tb01082.x.
4
Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia.醋丁洛尔。其药理学特性及在高血压、心绞痛和心律失常治疗中的疗效综述。
Drugs. 1985 Jun;29(6):531-69. doi: 10.2165/00003495-198529060-00003.
本文引用的文献
1
Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise.自主神经系统对心率的控制。关于人体压力感受器机制与运动之间相互关系的研究。
Circ Res. 1966 Aug;19(2):400-11. doi: 10.1161/01.res.19.2.400.
2
Plasma levels and beta-adrenoceptor blockade with acebutolol, practolol and propranolol in man.人血浆中醋丁洛尔、心得宁和普萘洛尔的水平及β-肾上腺素能受体阻滞作用
Br J Clin Pharmacol. 1975 Feb;2(1):49-55. doi: 10.1111/j.1365-2125.1975.tb00471.x.
3
The effect on blood pressure of beta-adrenoceptor blocking drugs administered once daily and their duration of action when therapy is ceased.每日服用一次的β-肾上腺素能受体阻断药物对血压的影响及其停药后的作用持续时间。
Br J Clin Pharmacol. 1976 Oct;3(5):857-61. doi: 10.1111/j.1365-2125.1976.tb00638.x.
4
Atenolol once-daily in hypertension.阿替洛尔每日一次用于治疗高血压。
Br J Clin Pharmacol. 1977 Oct;4(5):523-7. doi: 10.1111/j.1365-2125.1977.tb00780.x.
5
Contribution of atenolol, bendrofluazide, and hydrallazine to management of severe hypertension.阿替洛尔、苄氟噻嗪和肼苯哒嗪在重度高血压治疗中的作用。
Br Med J. 1977 Aug 27;2(6086):547-50. doi: 10.1136/bmj.2.6086.547.
6
Acute and long-term studies of the mechanisms of action of beta-blocking drugs in lowering blood pressure.β受体阻滞剂降压作用机制的急性和长期研究
Am J Med. 1976 May 31;60(6):853-65. doi: 10.1016/0002-9343(76)90905-0.
7
Problems in assessing beta-adrenoceptor antagonism in man.评估人体β-肾上腺素能受体拮抗作用的问题。
Br J Clin Pharmacol. 1975 Feb;2(1):3-4. doi: 10.1111/j.1365-2125.1975.tb01690.x.
Zotero 插件