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成功治疗的急性间质性肺炎。

SUCCESSFULLY TREATED ACUTE INTERSTITIAL PNEUMONIA.

作者信息

Gomerčić Palčić Marija, Turalija Ivan, Vrbanić Luka, Folnožić Ivana, Basioli Kasap Eugenija, Ulamec Monika

机构信息

Sestre milosrdnice University Hospital Center, Zagreb; Croatia.

University of Zagreb, School of Medicine, Zagreb, Croatia.

出版信息

Acta Clin Croat. 2022 Dec;61(4):722-726. doi: 10.20471/acc.2022.61.04.21.

Abstract

Acute interstitial pneumonia (AIP) is a rare idiopathic interstitial pneumonia with histology finding of diffuse alveolar damage (DAD). It is characterized by progressive hypoxic respiratory failure, high mortality rate, and absence of guidelines for its treatment. Here we present a case of a 64-year-old woman with progressive dyspnea, acute respiratory failure, diffuse bilateral reticulonodular opacities on standard chest radiograph, diffuse ground-glass opacities on computed tomography, and biopsy proven DAD. Diagnosis of AIP was established after extensive work-up that excluded the known risk factors for acute respiratory distress syndrome. Oxygen therapy and high-dose parenteral corticosteroids led to gradual improvement and resulted in complete respiratory recovery. Since there are no existing guidelines for treating AIP, more case reports and case series if not randomized control trials are warranted in order to define the most effective therapeutic modality.

摘要

急性间质性肺炎(AIP)是一种罕见的特发性间质性肺炎,组织学表现为弥漫性肺泡损伤(DAD)。其特征为进行性低氧性呼吸衰竭、高死亡率且缺乏治疗指南。在此,我们报告一例64岁女性病例,该患者有进行性呼吸困难、急性呼吸衰竭,标准胸部X线片显示双侧弥漫性网状结节状阴影,计算机断层扫描显示弥漫性磨玻璃影,活检证实为DAD。在排除急性呼吸窘迫综合征的已知危险因素后,经过广泛检查确诊为AIP。氧疗和大剂量肠外糖皮质激素治疗使病情逐渐改善,最终呼吸完全恢复。由于目前尚无治疗AIP的指南,因此有必要开展更多病例报告和病例系列研究(若无法进行随机对照试验),以确定最有效的治疗方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e2/10588378/f65f5b73a341/acc-61-722-f1.jpg

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