Olson J, Colby T V, Elliott C G
Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
Mayo Clin Proc. 1990 Dec;65(12):1538-48. doi: 10.1016/s0025-6196(12)62187-9.
In this article, we retrospectively review 29 cases of Hamman-Rich syndrome. As in some other recent reports, we have used the term "acute interstitial pneumonia" to emphasize the clinical and pathologic features of these cases and to distinguish them from the more common chronic interstitial pneumonias, particularly idiopathic pulmonary fibrosis. Of the 29 patients, 12 survived, some after a long and complicated hospitalization. The histologic features were those of organizing diffuse alveolar damage, and some patients, including survivors, had extensive fibroblastic distortion of lung parenchyma. The overall survival among these patients was not appreciably different from the survival of patients with the adult respiratory distress syndrome in general.
在本文中，我们回顾性分析了29例Hamman-Rich综合征病例。与其他近期报告一样，我们使用了“急性间质性肺炎”这一术语，以强调这些病例的临床和病理特征，并将它们与更常见的慢性间质性肺炎，尤其是特发性肺纤维化区分开来。29例患者中，12例存活，部分患者经过了漫长而复杂的住院治疗。组织学特征为机化性弥漫性肺泡损伤，一些患者，包括存活者，肺实质有广泛的成纤维细胞变形。这些患者的总体生存率与一般成人呼吸窘迫综合征患者的生存率并无明显差异。
