神经降压素刺激大鼠胰腺外分泌。
Neurotensin stimulates pancreatic exocrine secretion in rats.
作者信息
Khalil T, Fujimura M, Greeley G H, Townsend C M, Thompson J C
出版信息
Regul Pept. 1986 Oct;15(3):279-84. doi: 10.1016/0167-0115(86)90069-8.
Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.
神经降压素（NT）可刺激犬类和人类的胰腺外分泌。本研究的目的是检测外源性神经降压素对大鼠胰腺外分泌的影响。选用5只雄性Sprague-Dawley大鼠，制作胰腺、胃和十二指肠瘘。将胆汁分流至十二指肠以收集纯胰液。24小时后，以随机方式静脉注射神经降压素（0.05、0.1、0.2、0.3、1.0 nmol/kg）。每10分钟收集一次胰液，记录体积，并测定蛋白质和碳酸氢盐含量。神经降压素以剂量相关的方式刺激胰腺分泌水、蛋白质和碳酸氢盐。神经降压素可能参与大鼠胰腺分泌的生理调节。
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