衰老对大鼠胰腺分泌的影响。

Effect of aging on pancreatic secretion in rats.

作者信息

Khalil T, Fujimura M, Townsend C M, Greeley G H, Thompson J C

出版信息

Am J Surg. 1985 Jan;149(1):120-5. doi: 10.1016/s0002-9610(85)80020-9.

Abstract

We have characterized the effects of aging on the pancreatic exocrine secretory response to the normal stimulatory hormones, secretin, and cholecystokinin. Young (6 month old) and aged (26 months old) male Sprague-Dawley rats were prepared with pancreatic fistulas and challenged with different doses of secretin (0.03, 0.06, and 0.12 nmol/kg) and cholecystokinin-8 (0.3, 0.6, and 1.2 nmol/kg) intravenously. The pancreatic secretion was measured for volume and bicarbonate and protein outputs. Our results show that in aged rats, the basal pancreatic secretion volume and protein and bicarbonate outputs were significantly reduced, and the pancreatic secretion volume and protein and bicarbonate responses to graded doses of secretin or cholecystokinin-8 were significantly reduced. This study demonstrates that pancreatic exocrine function in rats diminishes with age.

摘要

我们已经研究了衰老对胰腺外分泌对正常刺激激素（促胰液素和胆囊收缩素）分泌反应的影响。将年轻（6个月大）和年老（26个月大）的雄性Sprague-Dawley大鼠制备成胰腺瘘，并静脉注射不同剂量的促胰液素（0.03、0.06和0.12 nmol/kg）和胆囊收缩素-8（0.3、0.6和1.2 nmol/kg）。测量胰腺分泌的体积、碳酸氢盐和蛋白质输出量。我们的结果表明，在老年大鼠中，基础胰腺分泌体积以及蛋白质和碳酸氢盐输出量显著降低，并且胰腺分泌体积以及蛋白质和碳酸氢盐对不同剂量促胰液素或胆囊收缩素-8的反应也显著降低。这项研究表明，大鼠的胰腺外分泌功能会随着年龄增长而减退。