Cui TongFeng, Sun HongYan, Hu ZiZhong, Shi YaBo, Zhu Jiang, Jin ManMan, Qin Bing
Department of Ophthalmology, Suqian First Hospital, Suqian, China.
Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
J Ophthalmol. 2023 Oct 14;2023:1609332. doi: 10.1155/2023/1609332. eCollection 2023.
This study aimed to evaluate conjunctival vessels in patients with dry eye disease (DED) using optical coherence tomography angiography (OCTA).
This was a cross-sectional, observational clinical study. Twenty-three eyes of 18 patients with DED and 28 eyes of 23 healthy controls were included for examination in this study. The evaluation included the application of an Ocular Surface Disease Index Questionnaire, Schirmer Basic Secretion Test, and anterior OCTA targeting the temporal conjunctiva. AngioTool software was used to quantify the total vessel length and vessel density in the 3 × 3 mm temporal region of interest.
Blood vessel density measurements were compared across the OCTA systems. The total vessel length within the conjunctiva of the DED group (4799.34 ± 834.36) exceeded that of the control eye (3864.89 ± 1455.70) group ( < 0.05). However, the difference in vessel density between the two groups was not statistically significant.
Measurement and analysis of conjunctival blood vessels using OCTA exhibited robust repeatability. In dry eyes, the total number of conjunctival blood vessels increased in accordance with disease severity. Hypoxia of conjunctival tissue may be an important cause of dry eye disease.
本研究旨在使用光学相干断层扫描血管造影（OCTA）评估干眼疾病（DED）患者的结膜血管。
这是一项横断面观察性临床研究。本研究纳入了18例DED患者的23只眼和23名健康对照者的28只眼进行检查。评估包括应用眼表疾病指数问卷、Schirmer基础分泌试验，以及针对颞侧结膜的眼前段OCTA。使用AngioTool软件对颞侧3×3mm感兴趣区域内的血管总长度和血管密度进行量化。
对不同OCTA系统的血管密度测量结果进行了比较。DED组结膜内的血管总长度（4799.34±834.36）超过了对照眼组（3864.89±1455.70）（P<0.05）。然而，两组之间的血管密度差异无统计学意义。
使用OCTA测量和分析结膜血管具有很强的可重复性。在干眼中，结膜血管总数随疾病严重程度增加。结膜组织缺氧可能是干眼疾病的一个重要原因。
