Gupta Vinod Kumar, Mohanty Tushar Kumar, Bhakat Mukesh, Dewry Raju Kumar, Katiyar Rahul, Nain Dipti, Shah Nadeem, Sethi Manisha, Rautela Rupali, Singh Mahak, Deori Sourabh
Artificial Breeding Research Centre (ABRC), ICAR-National Dairy Research Institute, Karnal, India.
Division of Animal and Fisheries Sciences, ICAR Research Complex for NEH Region, Umiam, Meghalaya, India.
Front Vet Sci. 2023 Oct 5;10:1248604. doi: 10.3389/fvets.2023.1248604. eCollection 2023.
Infertility is one of the primary factors for cattle reproduction in the present scenario. Reproduction-related immunoinfertility mainly involves immunization against the antigens related to reproductive hormones (LHRH, GnRH, Gonadal steroids, PGF2α and oxytocin), spermatozoa, seminal plasma and ovum. Anovulation, delayed ovulation, sperm immobilization, failure of fertilization, prolonged uterine involution, extended calving interval, prolonged post-partum estrus and reduced conception rate could be a result of immunoinfertility that occur due to the blockage of receptor site by antibodies formed against hormones, sperm and ovum. Immunoinfertility can be treated in the animal by giving sexual rest to females, by using various reproductive technologies such as fertilization, gamete intra fallopian tube transfer, and intracytoplasmic sperm injection, sperm washing and by treating the animals with immunomodulators such as LPS, Oyster glycogen, etc. This review summarizes the different causes of bovine reproductive immunoinfertility and amelioration strategies to overcome it.
在当前情况下，不育是影响奶牛繁殖的主要因素之一。与繁殖相关的免疫性不育主要涉及针对与生殖激素（促黄体生成素释放激素、促性腺激素释放激素、性腺类固醇、前列腺素F2α和催产素）、精子、精浆和卵子相关抗原的免疫反应。无排卵、排卵延迟、精子制动、受精失败、子宫复旧延长、产犊间隔延长、产后发情延长以及受胎率降低，可能是由于针对激素、精子和卵子形成的抗体阻断受体位点而导致的免疫性不育的结果。对于动物的免疫性不育，可以通过让雌性动物进行性休息、采用各种繁殖技术如受精、配子输卵管内移植、胞浆内单精子注射、精子洗涤，以及用脂多糖、牡蛎糖原等免疫调节剂对动物进行治疗来处理。本综述总结了牛生殖免疫性不育的不同原因及克服该问题的改善策略。
