Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China.
Adv Sci (Weinh). 2023 Dec;10(34):e2304190. doi: 10.1002/advs.202304190. Epub 2023 Oct 23.
The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for bone regeneration. Herein, inspired by the bone tissue composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) for bone regeneration is presented. With the help of microfluidic-assisted 3D printing technology, the composition and structure of the hybrid scaffold can be accurately controlled to meet clinical requirements. The combination of fish skin GelMa and PP also endowed the hybrid scaffold with good biocompatibility, cell adhesion, and osteogenic differentiation ability. Moreover, the controlled release of VEGF enables the scaffold to promote angiogenesis. Thus, the bone regeneration in the proposed scaffolds could be accelerated under the synergic effect of osteogenesis and angiogenesis, which has been proved in the rat skull defect model. These features indicate that the PP hybrid scaffolds will be an ideal candidate for bone regeneration in clinical applications.
通过模拟骨组织细胞外基质来开发生物活性支架，对于骨再生是有前景的。受骨组织组成的启发，本文提出了一种新型载有血管内皮生长因子（VEGF）的珍珠粉（PP）杂化鱼明胶甲基丙烯酰胺（GelMa）水凝胶支架，用于骨再生。借助微流控辅助 3D 打印技术，可以精确控制杂化支架的组成和结构，以满足临床需求。鱼皮 GelMa 与 PP 的结合也赋予了杂化支架良好的生物相容性、细胞黏附性和成骨分化能力。此外，VEGF 的控制释放使支架能够促进血管生成。因此，在协同成骨和血管生成的作用下，所提出的支架中的骨再生可以得到加速，这在大鼠颅骨缺损模型中得到了验证。这些特点表明，PP 杂化支架将是临床应用中骨再生的理想候选材料。
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