星形胶质细胞线粒体在限制缺血性脑损伤中的作用？
Role of Astrocytic Mitochondria in Limiting Ischemic Brain Injury?
机构信息
Children's Hospital of Philadelphia Research Institute , Philadelphia, Pennsylvania.
Children's Hospital of Philadelphia, Division of Neurology , Philadelphia, Pennsylvania.
出版信息
Physiology (Bethesda). 2018 Mar 1;33(2):99-112. doi: 10.1152/physiol.00038.2017.
Abstract
Until recently, astrocyte processes were thought to be too small to contain mitochondria. However, it is now clear that mitochondria are found throughout fine astrocyte processes and are mobile with neuronal activity resulting in positioning near synapses. In this review, we discuss evidence that astrocytic mitochondria confer selective resiliency to astrocytes during ischemic insults and the functional significance of these mitochondria for normal brain function.
摘要
直到最近，人们还认为星形胶质细胞的突起太小，无法容纳线粒体。然而，现在很清楚，线粒体存在于星形胶质细胞的细突起中，并随着神经元活动而移动，导致其定位在突触附近。在这篇综述中，我们讨论了星形胶质细胞中线粒体在缺血性损伤中赋予星形胶质细胞选择性弹性的证据，以及这些线粒体对正常大脑功能的功能意义。
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