Bondestam M, Håkansson L, Foucard T, Venge P
Scand J Clin Lab Invest. 1986 Nov;46(7):685-94. doi: 10.3109/00365518609083732.
Polymorphonuclear neutrophil (PMN) migration, phagocytosis, chemiluminescence production and chemotactic and chemokinetic activities in serum were investigated in 38 infection-prone children, aged 1 month to 15 years, and in healthy controls. The patients were grouped according to the clinical pattern, that is, into children with mainly upper respiratory tract infections, with frequent middle ear infections, with lower respiratory tract infections and with 'multifocal' infections occasionally accompanied by complications, and according to the severity of the infections. Forty-two defects were found in 28 of the 38 patients examined. Good accordance was found between clinical symptoms and abnormal PMN function. Several of the observed abnormalities are most likely inherited and primary causes of the increased susceptibility, but some of them probably occur as a consequence of the infections. The results indicate that defects in oxidative PMN metabolism and defects in Fc-receptor-dependent phagocytosis are major determinants of susceptibility to infection and that such defects seem to be especially common in patients with severe 'multifocal' infections.
对38名1个月至15岁易感染儿童及健康对照者的血清中多形核中性粒细胞（PMN）的迁移、吞噬作用、化学发光产生以及趋化和化学运动活性进行了研究。患者根据临床症状分组，即主要为上呼吸道感染的儿童、频繁中耳感染的儿童、下呼吸道感染的儿童以及偶尔伴有并发症的“多灶性”感染儿童，并根据感染的严重程度进行分组。在38名接受检查的患者中，有28名发现了42项缺陷。临床症状与PMN功能异常之间存在良好的一致性。观察到的一些异常很可能是遗传性的，是易感性增加的主要原因，但其中一些可能是感染的结果。结果表明，氧化型PMN代谢缺陷和Fc受体依赖性吞噬作用缺陷是易感染的主要决定因素，并且这些缺陷在患有严重“多灶性”感染的患者中似乎尤为常见。
