原发性干燥综合征患者的中性粒细胞功能：与感染易感性的关系。
Neutrophil function in patients with primary Sjögren's syndrome: relation to infection propensity.
作者信息
Gudbjörnsson B, Feltelius N, Hällgren R, Venge P
机构信息
Department of Medicine, University Hospital, Akademiska Sjukhuset, Uppsala, Sweden.
出版信息
Ann Rheum Dis. 1991 Oct;50(10):685-90. doi: 10.1136/ard.50.10.685.
The function of neutrophils was studied in 23 consecutive patients with primary Sjögren's syndrome and in 35 healthy controls. Nineteen patients (83%) had extraglandular symptoms and nine patients (39%) had recurrent bacterial infections. The patients had a marked reduction of neutrophil adherence, especially those with recurrent bacterial infections, and reduced opsonic activity of plasma. Increased random migration of isolated neutrophils was found in the patients with a propensity for bacterial infections. Chemotaxis and chemokinesis, phagocytosis, chemiluminescence production, and the intracellular neutrophil contents of lactoferrin and lysozyme were normal. The various aspects of neutrophil function tested in this study were not related to disease duration or to inflammatory disease activity. The impaired neutrophil adherence may play a part in the increased propensity for bacterial infections seen in patients with primary Sjögren's syndrome.
对23例原发性干燥综合征患者及35名健康对照者的中性粒细胞功能进行了研究。19例患者（83%）有腺外症状，9例患者（39%）有复发性细菌感染。患者中性粒细胞黏附力显著降低，尤其是有复发性细菌感染的患者，且血浆调理活性降低。在易发生细菌感染的患者中发现分离出的中性粒细胞随机迁移增加。趋化性和化学增活现象、吞噬作用、化学发光产生以及乳铁蛋白和溶菌酶的细胞内中性粒细胞含量均正常。本研究中测试的中性粒细胞功能的各个方面与疾病持续时间或炎症疾病活动无关。原发性干燥综合征患者中性粒细胞黏附受损可能在其细菌感染易感性增加中起作用。
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