Polácková M, Svec M, Viklický V
Folia Biol (Praha). 1979;25(2):95-100.
Neonatal skin grafts across a weak histocompatibility barrier (MSA-incompatible) were used only for sensitization of the recipients whose responsiveness was then tested in two different assays. On the basis of 1. functional inactivation of PEC in a PEC transfer system and 2. inhibition of macrophage migration. The difference between neonatal and adult skin grafts turned out to be quantitative rather than qualitative, i.e., both induced sensitization whose demonstration with the neonatal grafts required more sensitive techniques and/or more favourable timing because it was weaker. The possible nature of the difference, which was occasionally interpreted as being due to a tolerogenic rather than immunogenic activity of neonatal grafts, is discussed.
跨越弱组织相容性屏障（MSA不相容）的新生儿皮肤移植仅用于受体的致敏，然后在两种不同的试验中测试其反应性。基于1. 在PEC转移系统中PEC的功能失活和2. 巨噬细胞迁移的抑制。结果表明，新生儿和成人皮肤移植之间的差异是定量的而非定性的，即两者都诱导致敏，用新生儿移植证明致敏需要更敏感的技术和/或更有利的时机，因为其致敏作用较弱。文中讨论了这种差异可能的性质，这种差异偶尔被解释为是由于新生儿移植具有致耐受性而非免疫原性活性。
