Viklický V, Rossowski W, Polácková M, Skajster J
Folia Biol (Praha). 1975;21(6):375-81.
Prolonged survival of weakly incompatible skin allografts in mice (across the barrier presented by the MSA) can be induced by pretreating the recipients not only with a specific anti-MSA serum (obtained on day 5 after a single MSA-incompatible skin graft) but also be means of control serum obtained in a similar way from the recipients of fully compatible (syngeneic) skin grafts. Administration of serum from non-grafted mice had no effect on graft survival. The similar biological effect of both sera had a counterpart in their similar content and spectrum of glycosaminoglycans. Also in the skin grafts themselves, the course of both qualitative and quantitative changes of GAG in the early postgrafting period was in the allogeneic and syngeneic situation similar. The possible role of these substances in the serum and at the site of grafting and their effect on the outcome of the allograft response are discussed.
通过预处理受体，不仅使用特定的抗主要组织相容性抗原（MSA）血清（在单次MSA不相合皮肤移植后第5天获得），而且使用以类似方式从完全相合（同基因）皮肤移植受体获得的对照血清，可以诱导小鼠中弱不相合皮肤同种异体移植物（跨越MSA所呈现的屏障）的长期存活。给予未移植小鼠的血清对移植物存活没有影响。两种血清的相似生物学效应在其相似的糖胺聚糖含量和谱方面有对应表现。同样在皮肤移植物本身中，移植后早期糖胺聚糖的定性和定量变化过程在同种异体和同基因情况下是相似的。讨论了这些物质在血清中和移植部位的可能作用及其对同种异体移植反应结果的影响。
