Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 16440, Kista, Sweden.
Sci Rep. 2023 Oct 23;13(1):18122. doi: 10.1038/s41598-023-45154-8.
The ability to perform accurate continuous glucose monitoring without blood sampling has revolutionised the management of diabetes. Newer methods that can allow measurements during longer periods are necessary to substantially improve patients' quality of life. This paper presents an alternative method for glucose monitoring which is based on electrical impedance spectroscopy. A battery-less implantable bioimpedance spectroscope was designed, built, and used in an in vivo study on pigs. After a recovery period of 14 days post surgery, a total of 236 subcutaneous bioimpedance measurements obtained from intravenous glucose tolerance tests, with glucose concentration ranges between 77.4 and 523.8 mg/dL, were analyzed. The results show that glucose concentrations estimated by subcutaneous bioimpedance measurements correlate very well to the blood glucose reference values. The pigs were clinically healthy throughout the study, and the postmortem examinations revealed no signs of adverse effects related to the sensor. The implantation of the sensor requires minor surgery. The implant, being externally powered, could in principle last indefinitely. These encouraging results demonstrate the potential of the bioimpedance method to be used in future continuous glucose monitoring systems.
无需采血即可进行准确的连续血糖监测，这一技术革新了糖尿病的管理方式。为了极大地提高患者的生活质量，有必要开发出能够进行更长时间测量的新型方法。本文提出了一种基于电阻抗谱的葡萄糖监测替代方法。本文设计、制造了一种无电池植入式生物阻抗频谱仪，并在猪的体内研究中进行了使用。在手术后的 14 天恢复期后，总共进行了 236 次静脉葡萄糖耐量试验下的皮下生物阻抗测量，葡萄糖浓度范围为 77.4 至 523.8mg/dL，对其进行了分析。结果表明，皮下生物阻抗测量所估计的葡萄糖浓度与血糖参考值非常吻合。在整个研究过程中，猪都保持临床健康，尸检未发现与传感器相关的不良反应迹象。传感器的植入需要进行微创手术。该传感器由外部电源供电，理论上可以无限期使用。这些令人鼓舞的结果表明，生物阻抗方法有可能用于未来的连续血糖监测系统。
