School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
Sensors (Basel). 2020 Oct 31;20(21):6231. doi: 10.3390/s20216231.
Electrical methods are among the primarily studied non-invasive glucose measurement techniques; however, various factors affect the accuracy of the sensors used. Of these, the temperature is a critical factor; hence, the effects of temperature on the electrical properties of blood components are investigated in this study. Furthermore, the changes in the electrical properties of blood according to the glucose level are corrected by considering the effects of temperature on the electrical properties. An impedance sensor is developed and used to measure whole blood impedance in 10 healthy participants at various temperatures and glucose levels. Subsequently, the conductivities of the plasma and cytoplasm were extracted. Changes in the electrical properties of the blood components are then analyzed using linear regression and repeated measures ANOVA. The electrical conductivities of plasma and cytoplasm increased with increasing temperatures (plasma: 0.0397 (slope), 0.7814 (), cytoplasm: 0.014 (slope), 0.694 ()). At three values of increasing glucose levels (85.4, 158.1, and 271.8 mg/dL), the electrical conductivities of the plasma and cytoplasm decreased. These tendencies are more significant upon temperature corrections (-values; plasma: 0.001, 0.001, cytoplasm: 0.003, 0.002). The relationships between temperature and electrical conductivity changes can thus be used for temperature corrections in blood glucose measurement.
电学方法是研究最多的非侵入性血糖测量技术之一；然而，各种因素会影响传感器的准确性。在这些因素中，温度是一个关键因素；因此，本研究调查了温度对血液成分电学性质的影响。此外，通过考虑温度对电学性质的影响，对根据血糖水平变化的血液电学性质进行了校正。开发并使用阻抗传感器在不同温度和血糖水平下测量 10 名健康参与者的全血阻抗。随后，提取了血浆和细胞质的电导率。然后使用线性回归和重复测量 ANOVA 分析血液成分电学性质的变化。血浆和细胞质的电导率随温度升高而增加（血浆：0.0397（斜率），0.7814（），细胞质：0.014（斜率），0.694（））。在三个血糖水平升高（85.4、158.1 和 271.8 mg/dL）时，血浆和细胞质的电导率降低。温度校正后，这些趋势更为明显（-值；血浆：0.001，0.001，细胞质：0.003，0.002）。因此，温度与电导率变化之间的关系可用于血糖测量中的温度校正。
