State Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Phytother Res. 2024 Feb;38(2):470-488. doi: 10.1002/ptr.8049. Epub 2023 Oct 23.
Cerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy and posing a serious threat to human health. The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines. Paeonol is the main active component of traditional Chinese medicine Paeonia lactiflora Pall. It widely exists in many medicinal plants and has pharmacological effects such as anti-atherosclerosis, antiplatelet aggregation, anti-oxidation, and anti-inflammatory, which keeps generally used in the treatment of cardiovascular and cerebrovascular diseases. Based on the therapeutic effects of Paeonol for cardiovascular and cerebrovascular diseases, this article reviewed the pharmacological effects of Paeonol in Alzheimer's disease, Parkinson's disease, stroke, epilepsy, diabetes encephalopathy, and other neurological diseases, providing a reference for the research of the mechanism of Paeonol in central nervous system diseases.
脑血管疾病涉及神经元损伤，导致退行性神经病，严重威胁人类健康。从天然植物中发现有效药物成分并研究其作用机制是有别于化学合成药物的研究思路。丹皮酚是传统中药牡丹皮的主要活性成分，广泛存在于多种药用植物中，具有抗动脉粥样硬化、抗血小板聚集、抗氧化、抗炎等药理作用，常用于治疗心脑血管疾病。基于丹皮酚对心脑血管疾病的治疗作用，本文综述了丹皮酚在阿尔茨海默病、帕金森病、中风、癫痫、糖尿病脑病等神经系统疾病中的药理作用，为丹皮酚在中枢神经系统疾病中的作用机制研究提供参考。
