Department of Microbiology and Parasitology, School of Medicine, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarum 42610, Selangor, Malaysia.
Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Molecules. 2021 Aug 17;26(16):4976. doi: 10.3390/molecules26164976.
Paeonol is a naturally existing bioactive compound found in the root bark of and it is traditionally used in Chinese medicine for the prevention and management of cardiovascular diseases. To date, a great deal of studies has been reported on the pharmacological effects of paeonol and its mechanisms of action in various diseases and conditions. In this review, the underlying mechanism of action of paeonol in cardiovascular disease has been elucidated. Recent studies have revealed that paeonol treatment improved endothelium injury, demoted inflammation, ameliorated oxidative stress, suppressed vascular smooth muscle cell proliferation, and repressed platelet activation. Paeonol has been reported to effectively protect the cardiovascular system either employed alone or in combination with other traditional medicines, thus, signifying it could be a hypothetically alternative or complementary atherosclerosis treatment. This review summarizes the biological and pharmacological activities of paeonol in the treatment of cardiovascular diseases and its associated underlying mechanisms for a better insight for future clinical practices.
丹皮酚是一种天然存在的生物活性化合物，存在于 的根皮中，传统上用于中医预防和治疗心血管疾病。迄今为止，大量研究报道了丹皮酚在各种疾病和病症中的药理作用及其作用机制。在这篇综述中，阐明了丹皮酚在心血管疾病中的作用机制。最近的研究表明，丹皮酚治疗可改善内皮损伤、减轻炎症、改善氧化应激、抑制血管平滑肌细胞增殖和抑制血小板激活。丹皮酚单独或与其他传统药物联合使用可有效保护心血管系统，因此，它可能是一种潜在的替代或补充动脉粥样硬化治疗方法。本综述总结了丹皮酚在治疗心血管疾病及其相关潜在机制方面的生物学和药理学活性，以期为未来的临床实践提供更好的认识。
