Li Houkai, Dai Min, Jia Wei
Anhui College of Traditional Chinese Medicine, Hefei, PR China.
Planta Med. 2009 Jan;75(1):7-11. doi: 10.1055/s-0028-1088332. Epub 2008 Nov 10.
Cortex Moutan (Paeonia suffruticosa Andrews, Ranunculaceae) has several uses in traditional medicine, such as analgesic, antipyretic, and anti-inflammatory applications and use in the prevention of thromboembolic diseases. Paeonol, a main active component in Cortex Moutan, possesses various pharmacological activities, particularly an anti-atherosclerosis effect. However, so far there have been no reports evaluating the anti-inflammatory action of paeonol in atherosclerosis therapy. The purpose of this study was to investigate the association of the therapeutic effect of paeonol on atherosclerotic rabbits with its anti-inflammatory action. The atherosclerotic model was developed in 24 rabbits fed a high-fat diet for 12 weeks. Twelve rabbits on the high-fat diet then were administered with paeonol (p.o) for a subsequent 6 weeks at the doses of 75 mg/kg and 150 mg/kg. Histological analysis showed significant improvement in atherosclerosis plaque in the paeonol groups. Moreover, the blood levels of TNF- alpha, IL-1 beta, and CRP and the translocation of NF- kappaB to the nucleus were significantly suppressed in paeonol groups, as was the inhibition of lipid peroxidation. In conclusion, these findings suggest that the anti-inflammatory action of paeonol may contribute to its anti-atherosclerosis effect.
牡丹皮（毛茛科植物牡丹Paeonia suffruticosa Andrews）在传统医学中有多种用途，如止痛、退热、抗炎，以及用于预防血栓栓塞性疾病。丹皮酚是牡丹皮中的主要活性成分，具有多种药理活性，尤其是抗动脉粥样硬化作用。然而，迄今为止，尚无关于丹皮酚在动脉粥样硬化治疗中抗炎作用的报道。本研究的目的是探讨丹皮酚对动脉粥样硬化兔的治疗效果与其抗炎作用之间的关联。通过给24只兔子喂食高脂饮食12周建立动脉粥样硬化模型。然后，对12只高脂饮食的兔子以75 mg/kg和150 mg/kg的剂量口服丹皮酚，持续6周。组织学分析显示，丹皮酚组的动脉粥样硬化斑块有显著改善。此外，丹皮酚组的TNF-α、IL-1β和CRP的血液水平以及NF-κB向细胞核的转位均受到显著抑制，脂质过氧化也受到抑制。总之，这些发现表明丹皮酚的抗炎作用可能有助于其抗动脉粥样硬化作用。
