UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK.
J Cereb Blood Flow Metab. 2024 Apr;44(4):508-515. doi: 10.1177/0271678X231209641. Epub 2023 Oct 24.
Perivascular spaces mediate a complex interaction between cerebrospinal fluid and brain tissue that may be an important pathway for solute waste clearance. Their structural or functional derangement may contribute to the development of age-related neurogenerative conditions. Here, we employed a non-invasive low value diffusion-weighted ECG-gated MRI method to capture perivascular fluid movement around the middle cerebral artery of the anaesthetised rat brain. Using this method, we show that such MRI estimates of perivascular fluid movement directionality are highly sensitive to the cardiac cycle. We then show that these measures of fluid movement directionality are decreased in the angiotensin-II pharmacological model of acute hypertension, with an associated dampening of vessel pulsatility. This translational MRI method may, therefore, be useful to monitor derangement of perivascular fluid movement associated with cardiovascular pathologies, such as hypertension, in order to further our understanding of perivascular function in neurology.
血管周围空间介导了脑脊液和脑组织之间的复杂相互作用，这可能是溶质废物清除的重要途径。它们的结构或功能障碍可能导致与年龄相关的神经退行性疾病的发展。在这里，我们采用了一种非侵入性的低价值扩散加权心电图门控 MRI 方法来捕获麻醉大鼠脑的大脑中动脉周围的血管周围液体运动。使用这种方法，我们表明，这种 MRI 估计的血管周围液体运动方向对心脏周期非常敏感。然后，我们表明，在血管紧张素-II 急性高血压的药理学模型中，这种流体运动方向的测量值降低，并且血管搏动性减弱。因此，这种转化 MRI 方法可能有助于监测与心血管疾病（如高血压）相关的血管周围液体运动的紊乱，以进一步了解神经血管功能。
