Larsson K, Martinsson A, Hjemdahl P
Thorax. 1986 Jul;41(7):552-8. doi: 10.1136/thx.41.7.552.
The influence of circulating noradrenaline (in this context primarily a non-selective alpha agonist) and the alpha 1 selective agonist phenylephrine on bronchial tone, blood pressure, and heart rate was studied in eight patients with exercise induced asthma and eight age and sex matched controls. All subjects refrained from taking treatment for at least one week before the trial. The agonists were infused intravenously in stepwise increasing doses of 0.04, 0.085, 0.17, and 0.34 micrograms/kg a minute for noradrenaline and 0.5, 1.0, 2.0, and 4.0 micrograms/kg a minute for phenylephrine. At the highest dose the plasma concentration of noradrenaline was about 30 nmol/l, resembling the concentrations found during intense exercise, and that of phenylephrine was about 400 nmol/l. Both agonists caused dose dependent and similar increases in blood pressure in the two groups. Despite clearcut cardiovascular effects (systolic and diastolic blood pressure increased by about 40-50/25-30 mm Hg), neither agonist altered lung function, as assessed by measurements of specific airway compliance (sGaw), peak expiratory flow (PEF), or end expiratory flow rate, in either group. It is concluded that circulating alpha agonists, whether alpha 1 selective (phenylephrine) or non-selective (noradrenaline), fail to alter basal bronchial tone in patients with exercise induced asthma or in healthy subjects.
在8例运动诱发性哮喘患者和8例年龄及性别匹配的对照者中，研究了循环去甲肾上腺素（在此情况下主要是一种非选择性α激动剂）和α1选择性激动剂去氧肾上腺素对支气管张力、血压和心率的影响。所有受试者在试验前至少一周停止治疗。以每分钟0.04、0.085、0.17和0.34微克/千克的递增剂量静脉输注去甲肾上腺素激动剂，以每分钟0.5、1.0、2.0和4.0微克/千克的递增剂量静脉输注去氧肾上腺素激动剂。在最高剂量时，去甲肾上腺素的血浆浓度约为30纳摩尔/升，类似于剧烈运动时的浓度，而去氧肾上腺素的血浆浓度约为400纳摩尔/升。两种激动剂在两组中均引起剂量依赖性且相似的血压升高。尽管有明确的心血管效应（收缩压和舒张压分别升高约40 - 50/25 - 30毫米汞柱），但通过测量比气道顺应性（sGaw）、呼气峰值流速（PEF）或呼气末流速评估，两组中任何一种激动剂均未改变肺功能。得出的结论是，循环α激动剂，无论是α1选择性（去氧肾上腺素）还是非选择性（去甲肾上腺素），均不能改变运动诱发性哮喘患者或健康受试者的基础支气管张力。
