男性酒精依赖患者血清维生素 D 与甲状腺激素谱的关系。

Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence.

机构信息

Department of Material Dependence, Affiliated Psychological Hospital of Anhui Medical University, Hefei, 230022, China.

Anhui Clinical Research Center for Mental Disorders, Anhui Mental Health Center, Hefei, 230022, China.

出版信息

BMC Psychiatry. 2023 Oct 24;23(1):775. doi: 10.1186/s12888-023-05274-x.

DOI:10.1186/s12888-023-05274-x

PMID:37875902

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10594724/

Abstract

BACKGROUND

Alcohol dependence (AD) results in several medical problems including vitamin D deficiency and thyroid dysfunction. However, the relationship between these two complications remains unclear. The aim of the present study was to explore the relationship between serum vitamin D and thyroid hormone profiles in male patients with AD.

METHODS

A total of 117 male patients with AD were enrolled. Vitamin D deficiency was defined as serum concentrations of the main circulating vitamin D, 25-hydroxy vitamin D [25(OH)D], below 50 nmol/L. The AD patients were divided into two groups accordingly: 46 patients with normal vitamin D levels (normal group) and 71 patients with vitamin D deficiency (deficiency group). The levels of thyroid hormone profiles including total triiodothyronine 3 (TT3), total thyroxine 4 (TT4), thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) between the two groups were compared. Correlation between the serum levels of 25(OH)D and thyroid hormone profiles was evaluated using simple correlation (Pearson's correlation) and multivariable analysis using linear regression models.

RESULTS

The prevalence of vitamin D deficiency in male patients with AD is 60.7% (71/117; 95% confidence interval: 51.6-69.1%). Moreover, the serum levels of TT3 (t = -2.682, p = 0.009), TT4 (t = -2.033, p = 0.044), fT3 (t = -2.986, p = 0.003), and fT4 (t = -2.558, p = 0.012) in deficiency group were significantly higher than those in normal group. Post hoc power analyses showed that the power for fT3 was sufficient (power > 0.80). Furthermore, univariate analysis showed that the serum vitamin D levels were negatively correlated with the TT3 (r = -0.189, p = 0.044), fT3 (r = -0.350, p < 0.001), and fT4 (r = -0.198, p = 0.033) levels, while multivariate analysis indicated that only fT3 was independently related to the serum levels of vitamin D in male patients with AD.

CONCLUSIONS

These results suggested that the serum vitamin D levels may be associated with fT3 in male patients with AD.

摘要

背景

酒精依赖（AD）会导致多种医学问题，包括维生素 D 缺乏和甲状腺功能障碍。然而，这两种并发症之间的关系尚不清楚。本研究旨在探讨男性 AD 患者血清维生素 D 与甲状腺激素谱之间的关系。

方法

共纳入 117 例男性 AD 患者。维生素 D 缺乏定义为血清主要循环维生素 D（25-羟维生素 D [25(OH)D]）浓度低于 50 nmol/L。根据血清维生素 D 水平，AD 患者分为两组：46 例维生素 D 水平正常（正常组）和 71 例维生素 D 缺乏（缺乏组）。比较两组患者甲状腺激素谱（三碘甲状腺原氨酸 3（TT3）、甲状腺素 4（TT4）、促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）水平。采用简单相关（Pearson 相关）和多元线性回归模型评估血清 25(OH)D 水平与甲状腺激素谱之间的相关性。

结果

男性 AD 患者维生素 D 缺乏的患病率为 60.7%（71/117；95%置信区间：51.6-69.1%）。此外，缺乏组 TT3（t=-2.682，p=0.009）、TT4（t=-2.033，p=0.044）、fT3（t=-2.986，p=0.003）和 fT4（t=-2.558，p=0.012）水平明显高于正常组。事后功效分析显示，fT3 的功效充足（功效>0.80）。此外，单因素分析显示，血清维生素 D 水平与 TT3（r=-0.189，p=0.044）、fT3（r=-0.350，p<0.001）和 fT4（r=-0.198，p=0.033）水平呈负相关，而多元分析表明，只有 fT3 与男性 AD 患者的血清维生素 D 水平独立相关。