Lin Guojiao, Wang Jialiang, Yang Yong-Guang, Zhang Yuning, Sun Tianmeng
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, China.
National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China.
Front Bioeng Biotechnol. 2023 Oct 9;11:1242126. doi: 10.3389/fbioe.2023.1242126. eCollection 2023.
Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), play a key role in initiating the body's immune response, maintain the balance of immunity. DCs can also induce immune tolerance by rendering effector T cells absent and anergy, and promoting the expansion of regulatory T cells. Induction of tolerogenic DCs has been proved to be a promising strategy for the treatment of autoimmune diseases, organ transplantation, and allergic diseases by various laboratory researches and clinical trials. The development of nano-delivery systems has led to advances modulation of the tolerance phenotype of DCs. By changing the material composition, particle size, zeta-potential, and surface modification of nanoparticles, nanoparticles can be used for the therapeutic payloads targeted delivery to DCs, endowing them with great potential in the induction of immune tolerance. This paper reviews how nano-delivery systems can be modulated for targeted delivery to DCs and induce immune tolerance and reviews their potential in the treatment of autoimmune diseases, organ transplantation, and allergic diseases.
树突状细胞（DCs）是主要的专业抗原呈递细胞（APCs），在启动机体免疫反应、维持免疫平衡中起关键作用。DCs还可通过使效应T细胞缺失和无反应性以及促进调节性T细胞的扩增来诱导免疫耐受。通过各种实验室研究和临床试验，已证明诱导耐受性DCs是治疗自身免疫性疾病、器官移植和过敏性疾病的一种有前景的策略。纳米递送系统的发展推动了对DCs耐受表型的调控进展。通过改变纳米颗粒的材料组成、粒径、ζ电位和表面修饰，纳米颗粒可用于将治疗有效载荷靶向递送至DCs，使其在诱导免疫耐受方面具有巨大潜力。本文综述了纳米递送系统如何进行调控以靶向递送至DCs并诱导免疫耐受，并综述了它们在治疗自身免疫性疾病、器官移植和过敏性疾病中的潜力。
