对利福平耐药的结核分枝杆菌变异体的检测，博茨瓦纳，Xpert MTB/RIF 法无法检出。
Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana.
出版信息
Emerg Infect Dis. 2023 Nov;29(11):2403-2406. doi: 10.3201/eid2911.230987.
Abstract
GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre-extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.
摘要
GeneXpert MTB/RIF，一种广泛用于诊断结核病的工具，在检测某些变体的利福平耐药性方面存在局限性。我们报告了在博茨瓦纳传播的一种预先广泛耐药变体，该变体未被 GeneXpert 检测到。误诊的公共卫生影响强调了需要进行全面的分子检测以识别耐药性并指导治疗。
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