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2023 年 10 月，在德国接受治疗的一名乌克兰患者的 XDR 临床分离株中首次检测到 RpoB I491F 突变。

First detection of a XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023.

机构信息

Research Center Borstel, Leibniz Lung Center, Supranational and National Reference Center for Mycobacteria, Borstel, Germany.

German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.

出版信息

Euro Surveill. 2024 Jul;29(28). doi: 10.2807/1560-7917.ES.2024.29.28.2400420.

DOI:10.2807/1560-7917.ES.2024.29.28.2400420
PMID:38994601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241856/
Abstract

This report documents the case of a Ukrainian patient infected with an extensively drug-resistant (XDR) lineage 2 strain harbouring the rifampicin resistance mutation RpoB I491F. This mutation is not detected by routine molecular WHO-recommended rapid diagnostics, complicating the detection and treatment of these strains. The occurrence of such mutations underscores the need for enhanced diagnostic techniques and tailored treatment regimens, especially in eastern Europe where lineage 2 strains and XDR-tuberculosis are prevalent.

摘要

本报告记录了一例乌克兰患者感染利福平耐药突变 RpoB I491F 的广泛耐药（XDR）株 2 型菌株的情况。这种突变不能被常规的分子 WHO 推荐的快速诊断检测到，这增加了这些菌株的检测和治疗的复杂性。这种突变的出现突显了需要增强诊断技术和制定个体化的治疗方案，特别是在东欧，那里 2 型菌株和广泛耐药结核病流行。

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Letter to the Editor: First detection of a XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023.致编辑的信：2023年10月，在德国接受治疗的一名乌克兰患者中首次检测到携带RpoB I491F突变的广泛耐药临床分离株。
Euro Surveill. 2024 Oct;29(42). doi: 10.2807/1560-7917.ES.2024.29.42.2400665.

本文引用的文献

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Lancet Infect Dis. 2024 Mar;24(3):297-307. doi: 10.1016/S1473-3099(23)00498-X. Epub 2023 Nov 10.
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