儿童和青少年新发癌症患者的体能状况：系统评价和荟萃分析。
Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta-analysis.
机构信息
Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Department of Occupational Therapy and Physiotherapy, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
出版信息
Pediatr Blood Cancer. 2024 Jan;71(1):e30746. doi: 10.1002/pbc.30746. Epub 2023 Oct 25.
OBJECTIVE
To review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022.
METHODS
Thirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed.
RESULTS
Fifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random-effects meta-analysis was conducted to synthesize the results. No adverse events were reported related to testing.
CONCLUSION
Children with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.
目的
回顾新诊断癌症儿童的心肺功能、肌肉力量和身体表现的证据，于 2022 年 12 月 19 日在五个数据库（MEDLINE、Embase、CINAHL、CENTRAL 和 Web of Science）中进行了搜索。
方法
纳入了 13 项研究，共 594 名参与者，均在癌症诊断后 1 个月内，以及 3674 名健康对照者。分析了心肺功能（n=2）、肌肉力量（n=5）、身体表现（n=10）和不良事件（n=1）的 18 个不同结局。
结果
与健康对照者相比，17 项身体能力结果中有 15 项显示出严重的损伤。在可能的情况下，进行了随机效应荟萃分析以综合结果。未报告与测试相关的不良事件。
结论
癌症儿童在诊断后第一个月内心肺功能、肌肉力量和身体表现受损。然而，证据基于少数具有较大临床异质性的研究，限制了证据的确定性。
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