Graduate Program in Rehabilitation Sciences and Physical and Functional Performance, Physical Therapy School, Universidade Federal de Juiz de Fora, Avenida Eugênio Do Nascimento, S/N, Bairro Dom Bosco, Juiz de Fora, Minas Gerais, CEP: 36038-330, Brazil.
Eur J Pediatr. 2024 Nov 19;184(1):28. doi: 10.1007/s00431-024-05827-6.
During and after childhood cancer treatment, impairments in physical fitness are observed, such as reduced muscle strength, fatigue, and changes in body functions. These aspects may result in limitations and restrictions in performance of daily activities. To analyze the relationship between upper and lower limb muscle strength, functional mobility, and performance in activities daily living in children, adolescents, and young adults with cancer, compared to their healthy peers. The cross-sectional observational study involves 45 participants, 15 in the cancer group and 30 in the control group. Personal, environmental, and health data were collected. Participants from both groups were evaluated for upper and lower limb muscle strength, functional mobility (timed up and go test-TUG and five times sit-to-Stand test-5xSTS), and performance in activities of daily living (Pediatric Evaluation Of Disability Inventory-Computer Adaptive Test-PEDI-CAT). The participants were 30 females and 15 males (13.67 ± 5.78 years: cancer group; 13.07 ± 5.11 years: control group). Acute lymphoblastic leukemia (n = 7), chronic myeloid leukemia (n = 2) and Hodgkin's lymphoma (n=2) were the main diagnoses in the cancer group. No significant differences were found in upper and lower limb muscle strength between groups (p > 0.05). However, significant differences were observed in functional mobility (TUG and 5xSTS) and performance (PEDI-CAT-mobility) in activities of daily living, with the cancer group showing worse performance compared to the control group (p ≤ 0.001). Conclusion: Children and adolescents with cancer showed lower functional mobility and performance in activities of daily living compared to the control group. These difficulties were not associated with muscle weakness or level of physical activity. Therefore, it is recommended that physiotherapeutic treatment and follow-up include activities focused on mobility and functional independence.
在儿童癌症治疗期间和之后，会观察到身体适应性的损害，例如肌肉力量减弱、疲劳和身体功能的变化。这些方面可能导致日常活动的表现受限和受限。为了分析癌症儿童、青少年和年轻人与健康同龄人相比上肢和下肢肌肉力量、功能性移动性以及日常生活活动表现之间的关系。本横断面观察性研究涉及 45 名参与者，癌症组 15 名，对照组 30 名。收集个人、环境和健康数据。两组参与者均接受上肢和下肢肌肉力量、功能性移动性（计时起立行走测试-TUG 和五次坐站测试-5xSTS）和日常生活活动表现（残疾儿童评估量表-计算机自适应测试-PEDI-CAT）的评估。参与者中有 30 名女性和 15 名男性（癌症组：13.67±5.78 岁；对照组：13.07±5.11 岁）。急性淋巴细胞白血病（n=7）、慢性髓性白血病（n=2）和霍奇金淋巴瘤（n=2）是癌症组的主要诊断。两组上肢和下肢肌肉力量无显著差异（p>0.05）。然而，功能性移动性（TUG 和 5xSTS）和日常生活活动表现（PEDI-CAT-移动性）存在显著差异，癌症组表现明显差于对照组（p≤0.001）。结论：与对照组相比，癌症儿童和青少年的功能性移动性和日常生活活动表现较差。这些困难与肌肉无力或体力活动水平无关。因此，建议物理治疗治疗和随访包括以移动性和功能性独立性为重点的活动。
