抗高血压药物治疗期间左心室肥厚的消退
Regression of left ventricular hypertrophy during treatment with antihypertensive agents.
作者信息
Hill L S, Monaghan M, Richardson P J
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 2(Suppl 2):255S-260S. doi: 10.1111/j.1365-2125.1979.tb04698.x.
Abstract
1 Echocardiography showed 14 of 24 patients with essential hypertension to have hypertrophy of their left ventricular walls. In eight of these 14 patients the left ventricular configuration initially fulfilled the criteria for asymmetric septal hypertrophy (ASH) and six were symmetrically hypertrophied, the remaining ten being normal. 2 Following 12 weeks' treatment of hypertension with the object of reducing the supine BP to 150/90 mmHg or below, there was a reduction of wall thickness so that only two of the eight continued to show ASH. 3 The six patients with symmetrical left ventricular hypertrophy also showed a significant reduction in the thickness of the septum and the posterior wall. Those with normal echocardiograms did not change. 4 This reduction of wall thickness produced by antihypertensive therapy may represent regression of left ventricular hypertrophy.
摘要
- 超声心动图显示，24例原发性高血压患者中有14例存在左心室壁肥厚。在这14例患者中，8例患者的左心室形态最初符合非对称性室间隔肥厚（ASH）的标准，6例为对称性肥厚，其余10例正常。2. 以将仰卧位血压降至150/90 mmHg或更低为目标，对高血压进行12周治疗后，室壁厚度有所减少，以至于8例患者中只有2例继续表现为ASH。3. 6例对称性左心室肥厚患者的室间隔和后壁厚度也显著降低。超声心动图正常的患者没有变化。4. 降压治疗导致的室壁厚度减少可能代表左心室肥厚的消退。
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