每日一次使用噻吗洛尔控制血压并减轻经超声心动图评估的左心室质量。
Control of blood pressure and reduction of echocardiographically assessed left ventricular mass with one-daily timolol.
作者信息
Rowlands D B, Glover D R, Stallard T J, Littler W A
出版信息
Br J Clin Pharmacol. 1982 Jul;14(1):89-95. doi: 10.1111/j.1365-2125.1982.tb04939.x.
Abstract
1 Ten untreated hypertensive patients underwent 24 h continuous intra-arterial ambulatory monitoring of blood pressure (BP) and M-mode echocardiography. 2 They were treated with once-daily timolol and followed up at 2, 4, 8 and 12 weeks when dosage was titrated against BP control (indirect measurement) and degree of beta-adrenoceptor antagonism (submaximal bicycle ergometry and sub-lingual GTN). 3 Sixteen weeks after commencing therapy, nine patients underwent repeat continuous ambulatory monitoring of BP and M-mode echocardiography. 4 Casual BP was significantly reduced during the follow-up period at 2, 4, 8 and 12 weeks. 5 A reduction of BP was seen throughout the 24 h although this did not achieve statistical significance when sympathetic activity was low. 6 Echocardiographic measurement of left ventricular mass was significantly reduced after 16 weeks treatment.
摘要
10名未经治疗的高血压患者接受了24小时连续动脉动态血压监测和M型超声心动图检查。
他们接受每日一次的噻吗洛尔治疗，并在第2、4、8和12周进行随访，根据血压控制情况（间接测量）和β-肾上腺素能受体拮抗程度（次极量踏车运动试验和舌下含服硝酸甘油）调整剂量。
开始治疗16周后，9名患者再次接受连续动态血压监测和M型超声心动图检查。
在随访期间的第2、4、8和12周，偶测血压显著降低。
尽管在交感神经活动较低时24小时血压下降未达到统计学意义，但在整个24小时内血压均有下降。
治疗16周后，左心室质量的超声心动图测量值显著降低。
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