Reuben J M, Tanner C E, Portelance V
Infect Immun. 1979 Mar;23(3):582-6. doi: 10.1128/iai.23.3.582-586.1979.
Previous works has indicated that cotton rats treated with Mycobacterium bovis strain BCG are effectively protected against an infection with the metastatically proliferating metacestodes of Echinococcus multilocularis. In an attempt to induce a similar protection in the absence of tubercular granulomatous lesions, cotton rats were treated with BCG cell walls. A single injection of 150 micrograms of cell walls, emulsified in mineral oil-Tween-saline, 2 weeks before the inoculation of the parasite completely protected the animals against infection with E. multilocularis. This protection was correlated with an increase in the numbers of monocytes and, as judged by acid phosphatase activity, an activation of these cells. This study shows that BCG cell walls are as effective in protecting animals against E. multilocularis as the viable organism.
先前的研究表明，用牛分枝杆菌卡介苗菌株处理过的棉鼠能有效抵御多房棘球绦虫转移性增殖型囊尾蚴的感染。为了在没有结核性肉芽肿病变的情况下诱导类似的保护作用，用卡介苗细胞壁处理棉鼠。在接种寄生虫前2周，单次注射150微克乳化于矿物油-吐温-盐水中的细胞壁，可使动物完全抵御多房棘球绦虫的感染。这种保护作用与单核细胞数量的增加以及根据酸性磷酸酶活性判断的这些细胞的激活有关。这项研究表明，卡介苗细胞壁在保护动物抵御多房棘球绦虫方面与活生物体一样有效。
