School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
School of Athletic Performance, Shanghai University of Sport, Shanghai, China.
Front Endocrinol (Lausanne). 2023 Oct 10;14:1259650. doi: 10.3389/fendo.2023.1259650. eCollection 2023.
Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. Abnormalities in the cilia or ciliary transport system often cause a range of clinical conditions collectively known as ciliopathies, which include polydactyly, short ribs, scoliosis, thoracic stenosis and many abnormalities in the bones and cartilage. In this review, we summarize recent findings on the role of primary cilia and ciliary transport systems in bone development, we describe the role of cilia in bone formation, cartilage development and bone resorption, and we summarize advances in the study of primary cilia in fracture healing. In addition, the recent discovery of crosstalk between integrins and primary cilia provides new insights into how primary cilia affect bone.
原发性纤毛是一种基于微管的细胞器，广泛存在于细胞表面，通过感知和转导各种信号通路，在组织发育和稳态中发挥着关键作用。由驱动蛋白和动力蛋白推动的鞭毛内运输（IFT）过程对于纤毛的形成和功能至关重要。纤毛或纤毛运输系统的异常常导致一系列临床病症，统称为纤毛病，包括多指（趾）、肋骨短小、脊柱侧凸、胸椎狭窄和骨骼和软骨的许多异常。在这篇综述中，我们总结了原发性纤毛和纤毛运输系统在骨骼发育中的作用的最新发现，描述了纤毛在骨形成、软骨发育和骨吸收中的作用，并总结了原发性纤毛在骨折愈合研究中的进展。此外，最近发现整合素和原发性纤毛之间的串扰为原发性纤毛如何影响骨骼提供了新的见解。
