Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, ZP, Mexico.
Área de Biología y Salud Integral, Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa 91190, ZP, Mexico.
Curr Oncol. 2023 Sep 27;30(10):8793-8804. doi: 10.3390/curroncol30100634.
Breast cancer (BC) is the most frequent malignant neoplasia and leading cause of cancer mortality for women. A timely diagnosis of BC is crucial to ensure the best chances of survival. Among the various screening tools for BC, antibodies directed towards self-antigens or tumor-associated antigens (autoantibodies) have emerged as an alternative to image-based screening modalities. However, little attention has been paid to the global diversity of autoantibodies. This work aimed to analyze the diversity of autoantibodies reactive to antigens expressed by the BC cell line T47D in the sera of Mexican women with BC, benign breast pathology (BBP), or without breast pathology (WBP). We found that the diversity of antibodies in the sera was higher in the BC and BBP groups than in the WBP group. Likewise, the diversity changed with the progression of BC. Our results show and measure the complexity of the antibody response in breast health and disease.
乳腺癌（BC）是最常见的恶性肿瘤，也是女性癌症死亡的主要原因。及时诊断 BC 对于确保最佳生存机会至关重要。在 BC 的各种筛查工具中，针对自身抗原或肿瘤相关抗原（自身抗体）的抗体已成为基于图像的筛查方式的替代方法。然而，人们对自身抗体的全球多样性关注甚少。这项工作旨在分析在墨西哥患有 BC、良性乳腺病变（BBP）或无乳腺病变（WBP）的女性血清中针对 BC 细胞系 T47D 表达的抗原的自身抗体的多样性。我们发现，BC 和 BBP 组血清中的抗体多样性高于 WBP 组。同样，BC 的进展也改变了抗体的多样性。我们的研究结果表明并衡量了乳腺健康和疾病中抗体反应的复杂性。
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