Li Xiaonan, Wang Xuan, Cui Peicai, Liu Guangchao, Zhang Hui, Gao Yihan, Kai Zhenpeng
Shanghai New Tobacco Product Research Institute Co., Ltd., Shanghai 201315, China.
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Toxics. 2023 Sep 28;11(10):816. doi: 10.3390/toxics11100816.
The heated tobacco product (HTP) heats rather than burns tobacco to release an aerosol with significantly fewer toxicants than conventional cigarette smoke and has received global attention in recent years. To investigate whether changes in biomarkers of exposure could be detected after switching from conventional cigarettes (CCs) to HTPs, 224 subjects from four cities in China participated in this study. Nine biomarkers containing tobacco-specific nitrosamines (TSNAs), volatile organic compounds (VOCs), and the biomarkers for acrolein and crotonaldehyde were determined by UPLC-MS/MS. The levels of the sum of nine biomarkers in CCs were 5.4 and 5.2 times higher than in an Original-HTP and Menthol-HTP, respectively. Among the nine biomarkers, 3HPMA and 3HMPMA accounted for the highest proportions. Switching from CCs to HTPs is good for both men and women because the changes in each biomarker in urine samples were the same in men and women. Among all the subjects, subjects aged 20-39 years had the greatest reduction in biomarker residues in urine. The findings of the present study provided useful information for the health risk research of HTPs in China.
加热烟草制品（HTP）通过加热而非燃烧烟草来释放气溶胶，与传统香烟烟雾相比，其有毒物质显著减少，近年来受到全球关注。为了研究从传统香烟（CC）转换为HTP后是否能检测到暴露生物标志物的变化，来自中国四个城市的224名受试者参与了本研究。通过超高效液相色谱-串联质谱法测定了九种生物标志物，包括烟草特异性亚硝胺（TSNAs）、挥发性有机化合物（VOCs）以及丙烯醛和巴豆醛的生物标志物。CC中九种生物标志物总和的水平分别比原味HTP和薄荷醇HTP高5.4倍和5.2倍。在这九种生物标志物中，3HPMA和3HMPMA占比最高。从CC转换为HTP对男性和女性都有益，因为尿液样本中每种生物标志物对男性和女性的变化是相同的。在所有受试者中，20-39岁的受试者尿液中生物标志物残留量减少最多。本研究结果为中国HTP的健康风险研究提供了有用信息。
