Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Gheorghe Polizu 1-7 street, Bucharest, 011061, Romania.
National Center for Micro and Nanomaterials, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei 313, 060042, Bucharest, Romania.
Chempluschem. 2024 Mar;89(3):e202300450. doi: 10.1002/cplu.202300450. Epub 2023 Nov 20.
The current research aims to elucidate the influence of reduction process of TiO nanostructures on the surface properties of a bioinspired Ti modified implant, considering that the interface between a biomaterial surface and the living tissue plays an important role for this interaction. The production of reduced TiO nanotubes (RNT) with lower band gap is optimized and their performance is compared with those of simple TiO nanotubes (NT). The more conductive surfaces provided by the presence of RNT on Ti, allow a facile deposition of silk fibroin (SF) film using the electrochemical deposition method. This hybrid film is then functionalized with ZnO nanoparticles, to improve the antibacterial effect of the coating. The modified Ti surface is evaluated in terms of surface chemistry, morphology and roughness, wettability, surface energy, surface charge and antibacterial properties. Surface analysis such as SEM, AFM, FTIR and contact angle measurements were performed to obtain topographical features and wettability. FT-IR analysis confirms that SF was effectively attached to TiO nanotubes surfaces. The electrochemical deposition of SF and SF-ZnO reduced the interior diameter of nanotubes from ~85 nm to approx. 50-60 nm. All modified surfaces have a hydrophilic character.
本研究旨在阐明 TiO 纳米结构还原过程对仿生 Ti 改性植入物表面性能的影响，因为生物材料表面与活体组织之间的界面对于这种相互作用非常重要。优化了带隙较低的还原 TiO 纳米管（RNT）的制备，并将其性能与简单的 TiO 纳米管（NT）进行了比较。Ti 表面存在 RNT 提供了更具导电性的表面，使得使用电化学沉积法可以轻松沉积丝素蛋白（SF）薄膜。然后，通过在薄膜中掺杂 ZnO 纳米粒子对其进行功能化，以提高涂层的抗菌效果。通过表面化学、形貌和粗糙度、润湿性、表面能、表面电荷和抗菌性能来评估改性 Ti 表面。通过 SEM、AFM、FTIR 和接触角测量等表面分析方法获得了形貌和润湿性特征。FT-IR 分析证实 SF 有效地附着在 TiO 纳米管表面。SF 和 SF-ZnO 的电化学沉积将纳米管的内径从~85nm 降低至约 50-60nm。所有改性表面均具有亲水特性。
