与蜱虫和脊椎动物相关的荆门病毒的基因组进化。

Genomics evolution of Jingmen viruses associated with ticks and vertebrates.

机构信息

School of Public Health, the key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, China; Key Laboratory of Modern Pathogen Biology and Characteristics, Basic Medical College, Guizhou Medical University, Guiyang, Guizhou 550025, China.

Key Laboratory of Modern Pathogen Biology and Characteristics, Basic Medical College, Guizhou Medical University, Guiyang, Guizhou 550025, China; Department of Human Parasitology, Basic Medical College, Guizhou Medical University, Guiyang, Guizhou 550025, China.

出版信息

Genomics. 2023 Nov;115(6):110734. doi: 10.1016/j.ygeno.2023.110734. Epub 2023 Oct 27.

DOI:10.1016/j.ygeno.2023.110734

PMID:37890641

Abstract

Jingmen virus (JMV) associated with ticks and vertebrates have been found to be related to human disease. We obtained the genome of a Jingmen tick virus (JMTV) strain from Rhipicephalus microplus in Guizhou province and compared the genomes of seven JMV species associated with ticks and vertebrates to understand the evolutionary relationships. The topology of the phylogenetic tree of segment 1 and segment 3 is similar, and segment 2 and segment 4 formed two different topologies, with the main differences being between Alongshan virus (ALSV), Takachi virus, Yanggou tick virus and Pteropus lylei jingmen virus (PLJV), and the possibility of genetic reassortment among these viruses. Moreover, we detected recombination within JMTV and between PLJV and ALSV. The genetic reassortment and recombination that occurs during cross-species transmission of these JMV associated with ticks and vertebrates not only complicates their evolutionary relationships, but also raises the risk of these viruses to humans.

摘要

已发现与蜱和脊椎动物有关的荆门病毒（JMV）与人类疾病有关。我们从贵州省的微小牛蜱中获得了荆门 tick 病毒（JMTV）株的基因组，并比较了与蜱和脊椎动物有关的七种 JMV 物种的基因组，以了解进化关系。节段 1 和节段 3 的系统发育树拓扑结构相似，而节段 2 和节段 4 形成了两种不同的拓扑结构，主要区别在于 Alongshan 病毒（ALSV）、Takachi 病毒、Yanggou tick 病毒和 Pteropus lylei jingmen 病毒（PLJV）之间，以及这些病毒之间发生遗传重配的可能性。此外，我们在 JMTV 内部以及在 PLJV 和 ALSV 之间检测到重组。这些与蜱和脊椎动物有关的 JMV 在跨物种传播过程中发生的遗传重配和重组不仅使它们的进化关系复杂化，而且增加了这些病毒对人类的风险。