Xia Baicheng, Li Zhenhua, Zhu Wenbing, Wu Zhen, Zhang Yuli, Zhu Yujing, Sun Hengyi, Niu Guoyu
Shandong Second Medical University, Weifang, 261053, China.
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Virol J. 2024 Dec 20;21(1):325. doi: 10.1186/s12985-024-02587-5.
Jingmen tick virus (JMTV) is a novel segmented Flavivirus that was first identified from Rhipicephalus microplus in the Jingmen region of Hubei Province, China, in 2010. Subsequently, it was detected in a variety of countries and regions around the world. Meanwhile, JMTV has been proved to be pathogenic to humans and animals and could cause viremia in animals. However, the pathogenic mechanism of JMTV and what role animals play in the viral cycle have not yet been elucidated. In this study, 38 sheep sera were collected from Xinyang region of Henan Province, China and 204 ticks attached to the sheep were collected. The qRT-PCR and nested PCR were used to confirm the presence of JMTV in serum and tick samples. The results showed that the positive rate of JMTV in serum and ticks was 13.16% (5/38) and 7.84% (16/204), respectively. Phylogenetic analysis showed that JMTV sequences in sheep and ticks shared a high degree of identity with each other, and JMTV was relatively conserved in evolution. These results enriched the evidence for the prevalence of JMTV in animals and further deepened our understanding of the mechanisms and routes of JMTV transmission.
荆门蜱病毒（JMTV）是一种新型分段黄病毒，于2010年在中国湖北省荆门地区的微小扇头蜱中首次发现。随后，在世界各国和地区均检测到该病毒。同时，已证明JMTV对人和动物具有致病性，并可在动物体内引起病毒血症。然而，JMTV的致病机制以及动物在病毒传播循环中所起的作用尚未阐明。在本研究中，从中国河南省信阳市采集了38份绵羊血清，并收集了附着在绵羊身上的204只蜱。采用qRT-PCR和巢式PCR方法确认血清和蜱样本中JMTV的存在。结果显示，血清和蜱中JMTV的阳性率分别为13.16%（5/38）和7.84%（16/204）。系统发育分析表明，绵羊和蜱中的JMTV序列彼此具有高度同源性，且JMTV在进化过程中相对保守。这些结果丰富了JMTV在动物中流行的证据，并进一步加深了我们对JMTV传播机制和途径的理解。
