Sugimoto H, Monafo W W, Eliasson S G
Am J Physiol. 1986 Dec;251(6 Pt 2):H1211-6. doi: 10.1152/ajpheart.1986.251.6.H1211.
The regulation of peripheral nerve blood flow is incompletely understood. Regional blood flow in the rat sciatic nerve (NBF) and hamstring muscle (MBF) was measured in both conscious and anesthetized normal rats and in rats that had undergone surgical exposure of one sciatic nerve just prior to measurement. The distribution of [14C]butanol following its bolus intravenous injection was used to determine the flows in a modification of the "indicator fractionation" technique. NBF in normal rats was similar in limb pairs and was unaffected by pentobarbital sodium anesthesia. The pooled value was 12.5 +/- 1.1 ml X min-1 X 100 g-1. NBF was unaffected by sham operation in the conscious rats but was doubled in operated limbs of anesthetized rats (P less than 0.001). MBF in conscious normal rats was five times that measured during anesthesia. As in NBF, sham operation significantly increased MBF only in anesthetized rats (P less than 0.01). [14C]butanol distribution is a sensitive indicator of NBF and MBF. Mere surgical exposure of the nerve significantly increases NBF and MBF in anesthetized, but not in conscious rats.
对周围神经血流的调节尚未完全了解。在清醒和麻醉的正常大鼠以及在测量前刚刚对一侧坐骨神经进行手术暴露的大鼠中，测量大鼠坐骨神经（NBF）和绳肌（MBF）的局部血流。在改良的“指示剂分离”技术中，静脉注射[14C]丁醇后其分布用于确定血流。正常大鼠的NBF在双侧肢体中相似，并且不受戊巴比妥钠麻醉的影响。合并值为12.5±1.1 ml·min-1·100 g-1。清醒大鼠的假手术对NBF没有影响，但麻醉大鼠手术肢体的NBF增加了一倍（P<0.001）。清醒正常大鼠的MBF是麻醉期间测量值的五倍。与NBF一样，假手术仅在麻醉大鼠中显著增加MBF（P<0.01）。[14C]丁醇分布是NBF和MBF的敏感指标。仅仅神经的手术暴露就会显著增加麻醉大鼠的NBF和MBF，但不会增加清醒大鼠的NBF和MBF。
