Alkassar Muhnnad, Engelhardt Sophia, Abu-Tair Tariq, Ojeda Efren, Treffer Philipp C, Weyand Michael, Rompel Oliver
Department of Cardiac Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Department of Pediatrics, Paracelsus Medical School, General Hospital of Nuremberg, 90419 Nuremberg, Germany.
Diagnostics (Basel). 2023 Oct 10;13(20):3162. doi: 10.3390/diagnostics13203162.
This study investigates the crucial factors influencing the end-systolic and end-diastolic volumes in MRI volumetry and their direct effects on the derived functional parameters. Through the simultaneous acquisition of 2D-cine and 3D whole-heart slices in end-diastole and end-systole, we present a novel direct comparison of the volumetric measurements from both methods. A prospective study was conducted with 18 healthy participants. Both 2D-cine and 3D whole-heart sequences were obtained. Despite the differences in the creation of 3D volumes and trigger points, the impact on the LV volume was minimal (134.9 mL ± 16.9 mL vs. 136.6 mL ± 16.6 mL, < 0.01 for end-diastole; 50.6 mL ± 11.0 mL vs. 51.6 mL ± 11.2 mL, = 0.03 for end-systole). In our healthy patient cohort, a systematic underestimation of the end-systolic volume resulted in a significant overestimation of the SV (5.6 mL ± 2.6 mL, < 0.01). The functional calculations from the 3D whole-heart method proved to be highly accurate and correlated well with function measurements from the phase-contrast sequences. Our study is the first to demonstrate the superiority of 3D whole-heart volumetry over 2D-cine volumetry and sheds light on the systematic error inherent in 2D-cine measurements.
本研究调查了在MRI容积测量中影响收缩末期和舒张末期容积的关键因素及其对导出的功能参数的直接影响。通过在舒张末期和收缩末期同时采集二维电影和三维全心切片，我们对两种方法的容积测量进行了新颖的直接比较。对18名健康参与者进行了一项前瞻性研究。获得了二维电影和三维全心序列。尽管在三维容积创建和触发点方面存在差异，但对左心室容积的影响最小（舒张末期为134.9 mL±16.9 mL对136.6 mL±16.6 mL，<0.01；收缩末期为50.6 mL±11.0 mL对51.6 mL±11.2 mL，=0.03）。在我们的健康患者队列中，收缩末期容积的系统性低估导致每搏输出量的显著高估（5.6 mL±2.6 mL，<0.01）。三维全心方法的功能计算结果证明非常准确，并且与相位对比序列的功能测量结果相关性良好。我们的研究首次证明了三维全心容积测量优于二维电影容积测量，并揭示了二维电影测量中固有的系统误差。
