Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, China.
College of Life Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Curr Protein Pept Sci. 2022;23(4):226-247. doi: 10.2174/1389203723666220519155942.
Despite antimicrobial resistance, which is attributed to the misuse of broad-spectrum antibiotics, antibiotics can indiscriminately kill pathogenic and beneficial microorganisms. These events disrupt the delicate microbial balance in both humans and animals, leading to secondary infections and other negative effects. Antimicrobial peptides (AMPs) are functional natural biopolymers in plants and animals. Due to their excellent antimicrobial activities and absence of microbial resistance, AMPs have attracted enormous research attention. We reviewed the antibacterial, antifungal, antiviral, antiparasitic, as well as antitumor properties of AMPs and research progress on AMPs. In addition, we highlighted various recommendations and potential research areas for their progress and challenges in practical applications.
尽管抗生素的广泛使用导致了抗药性，但抗生素可以不分青红皂白地杀死病原微生物和有益微生物。这些事件破坏了人类和动物体内微妙的微生物平衡，导致二次感染和其他负面影响。抗菌肽 (AMPs) 是植物和动物中具有功能的天然生物聚合物。由于其出色的抗菌活性和不存在微生物耐药性，AMPs 引起了极大的研究关注。我们综述了 AMPs 的抗菌、抗真菌、抗病毒、抗寄生虫以及抗肿瘤特性以及 AMPs 的研究进展。此外，我们强调了各种建议和潜在的研究领域，以促进它们在实际应用中的进展和解决所面临的挑战。
